Download PDF
Synlett 2000; 2000(2): 254-256
DOI: 10.1055/s-2000-6481
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Transformation of 2H-Pyran-2-one ring: First Synthesis of Pyridazino[4,3-c]azepines and their Oxidation with Thallium(III) Nitrate or Copper(II) Acetate

Stanislav Kafka* , Polonca Trebše, Slovenko Polanc, Marijan Kočevar
  • *Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, SI-1000 Ljubljana, Slovenia; Fax +3 86 6 11 25 82 43; E-mail: marijan.kocevar@uni-lj.si
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A novel reaction starting from pyrano[3,2-c]azepines 1 and hydrazine hydrate was used for the preparation of the first derivatives of pyridazino[4,3-c]azepines 2. They were further oxidised by thallium(III) nitrate trihydrate (TTN) or copper(II) acetate hydrate (CuDA) to give aromatised fused pyridazine derivatives 5 also containing an ester function formed from the carbohydrazide moiety.

oxidation - esters - thallium(III) nitrate - copper(II) acetate - heterocycles - pyridazino[4,3-c]azepines

      >