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Semin Thromb Hemost 2000; 26(5): 495-502
DOI: 10.1055/s-2000-13205
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Impaired Endogenous Fibrinolysis in Diabetes Mellitus: Mechanisms and Therapeutic Approaches

Thomas K. Nordt, Christoph Bode
  • Department of Cardiology, University of Freiburg, Germany
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

In type II diabetes mellitus the activity of the endogenous fibrinolytic system is reduced secondary to increased plasma activity of the plasminogen activator inhibitor type 1 (PAI-1). Because PAI-1 is considered an independent risk factor for cardiovascular disease, increased PAI-1 activity in diabetes mellitus may partly explain the increased susceptibility to both primary atherosclerosis and restenosis after angioplasty in this disease. The factors contributing to increased PAI-1 expression in diabetes mellitus are reviewed as well as possible therapeutic approaches to normalize increased PAI-1 expression.

KEYWORD

Plasminogen activator inhibitor - PAI-1 - hyperglycemia - hyperinsulinemia - endothelium

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