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Synlett 1999; 1999(11): 1832-1834
DOI: 10.1055/s-1999-2937
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Optically Active Amine Derivatives: Ruthenium-Catalyzed Enantioselective Hydrogenation of Enamides

P. Dupau* , P. Le Gendre, C. Bruneau, P. H. Dixneuf
  • *UMR 6509: CNRS - Université de Rennes - Organométalliques et Catalyse, Campus de Beaulieu, 35042 Rennes Cedex, France; E-mail: christian.bruneau@univ-rennes1.fr
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Publication History

Publication Date:
31 December 1999 (online)

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Enamides have first been prepared by reaction of 5-methoxy-3-chromanone and 2-tetralone with primary amides under acidic conditions. The enantioselectivities observed in the asymmetric hydrogenation of these enamides using ruthenium catalysts strongly depended on both the starting ketone and the nature of the amide group.

ketone - enamide - enantioselective hydrogenation - ruthenium catalyst

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