Download PDF
Synlett 1998; 1998(8): 918-920
DOI: 10.1055/s-1998-1811
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Superacid Activated Condensation of Parabanic Acid and Derivatives with Arenes. A New Synthesis of Phenytoin and 5,5-Diarylhydantoins

Douglas A. Klumpp* , Ka Yeun Yeung, G. K. Surya Prakash, George A. Olah
  • *Department of Chemistry, California State Polytechnic University, Pomona, CA 91768
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A new synthetic route in phenytoin and 5,5-diarylhydantoins is reported. Parabanic acid is converted to the 5,5-diarylhydantoins (65-98% yield) from CF3SO3H and arenes. Deuterium substituted produts are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.

phenytoin - hydantoin - heterocycle - superacid - electrophile

      >