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Synlett 1997; 1997(4): 351-352
DOI: 10.1055/s-1997-803
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Zinc-Mediated Allylation of N-Protected α-Amino Aldehydes in Aqueous Solution. Stereoselective Synthesis of Phe-Phe Hydroxyethylene Dipeptide Isosteres

Stephen Hanessian* , Haeil Park, Rui-Yang Yang
  • *Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec, H3C 3J7, CANADA, Fax: (514) 343-5728; e-mail hanessia@ere.umontreal.ca
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Publication Date:
31 December 2000 (online)

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An efficient route for the synthesis of a Phe-Phe hydroxyethylene dipeptide isostere utilized for the design of potential inhibitors of renin and HIV-protease was developed.

hydroxyethylene dipeptide isosteres - allylation - γ-lactone - α-amino aldehydes

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