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Synlett 1997; 1997(SI): 401-410
DOI: 10.1055/s-1997-6114
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Synthesis of DNA-Binding Oligosaccharides

K.C. Nicolaou* , Brian M. Smith, Joaquin Pastor, Yoshihiko Watanabe, David S. Weinstein
  • *Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037 and Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, Fax: (619) 784-2469; E-mail: kcn@scripps.edu
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Publication Date:
31 December 2000 (online)

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Calicheamicin's oligosaccharide domain is endowed with striking DNA-binding properties targeting primarily TCCT, TCTC and TTTT duplex DNA sequences. In this account, we summarize our studies in this area which culminated in the total synthesis of a series of natural and designed oligosaccharides related to calicheamicin. A number of these compounds exhibited interesting DNA-binding properties and gene suppression activity.

oligosaccharide - DNA-binding

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