Download PDF
Synlett 1997; 1997(11): 1233-1234
DOI: 10.1055/s-1997-1029
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Direct N3 Alkylation of Uracil and Derivatives via n1-[2-(trimethylsilyl)ethoxymethyl] Protection

L. Arias, A. Guzmán, S. Jaime-Figueroa, F. J. Lopez* , D. J. Morgans Jr., F. Padilla, A. Pérez-Medrano, C. Quintero, M. Romero, L. Sandoval
  • *Roche Bioscience, 3401 Hillview Ave, Palo Alto, CA 93404, USA, Fax (650) 852-1875; francisco.lopez-tapia@roche.com
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Protection at N1 position of uracil and uracil analogs as 2-(trimethylsilyl)ethoxymethyl derivatives permits the clean alkylation at N3. These protected uracils are quite stable in a wide range of pH.

n1-uracil protection - regioselectivity - 1-[2-(trimethylsilyl)ethoxymethyl]-3-alkyluracils - pH stability - 3-alkyluracils

      >