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Synlett 1995; 1995(6): 599-602
DOI: 10.1055/s-1995-5025
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Biocatalysis in Organic Synthesis. 6. First Use of an Acylase as Catalyst in the Irreversible Transacylation of Alcohols and Amines: Application to Selective Transformations1

Bernardo Herradón* , Serafín Valverde
  • *Instituto de Química Orgánica General, C.S.I.C., c/ Juan de la Cierva 3, 28006 Madrid, Spain
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Publication History

Publication Date:
31 December 2000 (online)

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The acylase from Aspergillus species catalyzes the acylation of alcohols and amines using vinyl acetate as irreversible acyl-transfer reagent. This is the first time that this enzyme has been employed to catalyze this kind of reaction. The method has been used in chemo-, regio-, and enantioselective transformations.

Alcohol - amine - kinetic resolution - acylase - selective transformations

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