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Synlett 1994; 1994(11): 931-932
DOI: 10.1055/s-1994-23052
DOI: 10.1055/s-1994-23052
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Synthesis of α-[2H]-amines via photodecarboxylation of N-phthaloyl α-amino acids
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Publication History
Publication Date:
22 March 2002 (online)
N-phthaloyl activated α-amino acids can be efficiently decarboxylated with deuterium incorporation when irradiated in acetone / deuterium oxide mixtures or by irradiation of predeuterated N-phthaloyl α-amino acids (8 examples). Deprotection (hydrazinolysis) of these compounds leads to α-[2H]-amines with 95-99% deuterium content.