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Synthesis 1993; 1993(12): 1253-1256
DOI: 10.1055/s-1993-26037
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Synthesis of Optically Active 4-Benzyloxymethyl- and 4-(4-Methoxyphenoxy)methylbuten-2-olides via Lipase-Mediated Resolution

Seiichi Takano* , Masaki Setoh, Osamu Yamada, Kunio Ogasawara
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan
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Publication Date:
29 April 2002 (online)

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A new preparation of optically active 4-benzyloxymethyl- and 4-(4-methoxyphenoxy)methylbuten-2-olides has been developed by employing lipase-mediated resolution and palladium-mediated carbomethoxylation as key steps.