Download PDF
Synlett 1993; 1993(3): 215-216
DOI: 10.1055/s-1993-22407
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Polyene Macrolactam Construction Using a Stille Vinyl-Vinyl Coupling Protocol: An Approach to the Antitumour Antibiotic Substance Leinamycin

Gerald Pattenden* , Stephen M. Thom
  • *Department of Chemistry, The University, Nottingham NG7 2RD, England
Further Information

Publication History

Publication Date:
19 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A new approach to polyene macrolactam construction is described, based on an intramolecular Stille vinyl-vinyl coupling strategy, e.g. (10) → (12). The methodology is then applied to a synthesis of the macrolactam unit (17) found in the antitumour antibiotic substance leinamycin (1).

      >