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Synlett 1993; 1993(1): 40
DOI: 10.1055/s-1993-22339
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A Convenient Synthesis of 4-Alkylfuran-2-Acetic Acids

Robert W. Carling* , Paul D. Leeson
  • *Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, England
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Publication Date:
19 March 2002 (online)

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α-Chloroketones (2) are converted to 4-alkylfuran-2-acetic acids (1) by a 6-step procedure; the key transformation being regioselective ring opening of cyclic anhydrides (4) to form mono esters (5) exclusively.

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