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Synthesis 1992; 1992(4): 358-360
DOI: 10.1055/s-1992-26107
short paper
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Synthesis of 3′-(5-Amino-1,2,3,4-tetrazol-1-yl)-3′-deoxythymidines

Dieter Häbich*
  • *Bayer AG, Chemisch wissenschaftliches Labor-Pharma, Postfach 10 17 09, D-5600 Wuppertal 1, Germany
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Publication History

Publication Date:
17 September 2002 (online)

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A one-pot synthesis of the new 3′-(5-amino-1,2,3,4-tetrazol-1-yl)-3′-deoxythymidines from 3′-Azido-3′-deoxythymidine (AZT) is described. The key step is the 1,3-dipolar cycloaddition of hydrazoic acid to intermediate carbodiimides.