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Synlett 1992; 1992(4): 303-305
DOI: 10.1055/s-1992-21348
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Stereo- and Regioselective Metal Salt-Promoted Ring Opening of 1,2-Epoxides with Thiols in Acetonitrile

Marco Chini* , Paolo Crotti, Elena Giovani, Franco Macchia, Mauro Pineschi
  • *Dipartimento di Chimica Bioorganica, Università di Pisa, Via Bonanno 22, I-56126 Pisa, Italy
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Publication Date:
08 March 2002 (online)

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A simple efficient, stereoselective, and highly regioselective method for the synthesis of ß-hydroxy sulfides by the direct opening of 1,2-epoxides with thiols in anhydrous acetonitrile, in the presence of a metal salt, is described. This new method appears to be competitive with the other methods previously reported.

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