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Synlett 1992; 1992(1): 37-38
DOI: 10.1055/s-1992-21257
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Enzymatic Cleavage of tert-Butyl Esters: Thermitase-Catalyzed Deprotection of Peptides and O-Glycopeptides

Michael Schultz* , Peter Hermann, Horst Kunz
  • *Institut für Organische Chemie, Universität Mainz, Becherweg 18-20, D-6500 Mainz, Germany
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Publication Date:
18 September 2002 (online)

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The tert-butyl esters of differently N-protected peptides are selectively cleaved in a thermitase-catalyzed reaction without affecting the peptide bonds. Furthermore, an O-glycopeptide carrying a N-acetylglucosamine side chain readily undergoes the same selective deblocking reaction, thus demonstrating the broad scope of this method.

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