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Synthesis 1991; 1991(9): 689-691
DOI: 10.1055/s-1991-26545
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An Improved Method for the Synthesis of Active Esters of N-Protected Amino Acids and Subsequent Synthesis of Dipeptides

Kazuyoshi Takeda* , Akira Ayabe, Masako Suzuki, Yaeko Konda, Yoshihiro Harigaya
  • *Schoof of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108, Japan
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Publication Date:
29 April 2002 (online)

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4-Dimethylaminopyridine-catalyzed reaction of mixed carbonates 3 with N-protected amino acids 4 gave the corresponding active esters 5-9, from which dipeptides 11-18 were synthesized by aminolysis with amino acids 10.

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