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Synlett 1991; 1991(2): 115-116
DOI: 10.1055/s-1991-20648
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Chalcones via a Palladium-Catalyzed Coupling of Iodoheterocycles to 1-Phenyl-2-propyn-1-ol

Klemens Minn*
  • *Hoechst AG, Agricultural Division, D-6230 Frankfurt 80, Germany
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Publication Date:
07 March 2002 (online)

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A palladium-catalyzed coupling of nitrogen-containing iodoheterocycles 6, with the iodine atom bound to a carbon adjacent to nitrogen, to 1-phenyl-2-propyn-1-ol (7b) and subsequent base-catalyzed rearrangement produces (E)-chalcones (8 examples) in a simple one-pot procedure.

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