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Semin Neurol 2023; 43(04): 583-597
DOI: 10.1055/s-0043-1771461
Review Article

An Overview of Gastrointestinal Dysfunction in Parkinsonian Syndromes

Lauren Talman
1   Department of Neurology School of Medicine, Oregon Health & Science University, Portland, Oregon
,
Delaram Safarpour
1   Department of Neurology School of Medicine, Oregon Health & Science University, Portland, Oregon
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Abstract

Gastrointestinal (GI) dysfunction is a common nonmotor symptom in Parkinson's disease (PD) as well as other parkinsonian syndromes and may precede the onset of motor symptoms by decades. Involvement of all segments of the GI tract can lead to altered responses to medications and worsened quality of life for patients. While some GI symptoms occur in isolation, others overlap. Therefore, understanding the changes in different segments of the GI tract and how they relate to altered responses to PD treatment can guide both diagnostic and pharmacological interventions. Gut microbiota plays a critical role in immune activity and modulation of the enteric and central nervous systems. Understanding this bidirectional relationship helps to elucidate the pathogenesis of neurodegeneration. This review will describe the current understanding of how GI dysfunction develops in parkinsonian syndromes, common symptoms in PD and related disorders, and available treatments.

Keywords

Parkinson's disease - gastrointestinal dysfunction - atypical parkinsonism - gut - parkinsonism


Publikationsverlauf

Artikel online veröffentlicht:
13. September 2023

© 2023. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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