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Thromb Haemost 1986; 56(03): 397-400
DOI: 10.1055/s-0038-1661690
Original Article
Schattauer GmbH Stuttgart

Anticoagulant Effect of Sulphated Poly/Vinyl Alcohol-Acrylic Acid/Copolymers

Raymund Machovich
The 2nd Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary
,
Miklós Nagy
*   The Department of Colloid Science, Eötvös Loránd University, Budapest, Hungary
,
Judit Györgyi-Edelényi
*   The Department of Colloid Science, Eötvös Loránd University, Budapest, Hungary
,
Katalin Csomor
**   The Chemical Works of Gedeon Richter Ltd., Pharmacological Research Centre, Budapest, Hungary
,
István Horváth
The 2nd Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary
› Author Affiliations
Further Information

Publication History

Received 06 February 1986

Accepted after revision 26 September 1986

Publication Date:
28 August 2018 (online)

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Summary

Copolymers of poly/vinyl alcohol-acrylic acid/ with various content of sulphate and carboxyl groups have been synthetized and tested for their in vitro effect on blood coagulation. The results indicate that the sulphated copolymers display an inhibitory effect but there is a requirement in the charged groups of about 20% in the molecqle to possess effective anticoagulation. The biochemical mechanism of their actions is complex, i.e. the inhibition of blood clotting is a consequence of both (i) the accelerated inactivation rate of thrombin by antithrombin-III and (ii) a direct inhibitory effect on the thrombin-fibrinogen reaction. Moreover, additional effects may occur on other blood coagulation enzymes than thrombin, depending on the chemical composition of the copolymers.

Key words

Heparin - Heparin-like copolymers - Thrombin - Antithrombin III - Fibrinogen
 

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