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Thromb Haemost 1986; 56(02): 183-188
DOI: 10.1055/s-0038-1661636
Original Article
Schattauer GmbH Stuttgart

The Diurnal Increase in Euglobulin Fibrinolytic Activity in Women Using Oral Contraceptives and in Normal Women, and the Generation of Intrinsic Fibrinolytic Activity

Jørgen Jespersen
The Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital in Esbjerg, and Section for Thrombosis Research, South Jutland University Centre, Esbjerg, Denmark
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Further Information

Publication History

Received 08 October 1985

Accepted 10 July 1986

Publication Date:
20 July 2018 (online)

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Summary

The diurnal fluctuations in plasma euglobulin fibrinolytic activity in women on oral contraceptives and in normal women showed similar patterns of increase. Following inactivation of inhibitors by flufenamate the individual increases and the evening levels did not differ. The diurnal increase was related to an increase in extrinsic (tissue-type) plasminogen activator (t-PA) activity, which contributes little to the total activity of the euglobulin fraction but induces an activation of the intrinsic system.

Key words

Oral contraceptives - Menstrual cycle - Diurnal fibrinolytic activity - Extrinsic (tissue-type) plasminogen activator - Intrinsic plasminogen activators - Plasma euglobulin fibrinolytic activity
 

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