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Thromb Haemost 1986; 55(02): 259-262
DOI: 10.1055/s-0038-1661532
Original Article
Schattauer GmbH Stuttgart

The Systemic Fibrinolytic Effect of BRL 26921 During the Treatment of Acute Peripheral Arterial Occlusions

J J Earnshaw
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
,
J C Westby
2   The Department of Haematology, University Hospital, Nottingham, UK
,
G S Makin
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
,
B R Hopkinson
1   The Department of Vascular Surgery, University Hospital, Nottingham, UK
› Author Affiliations
Further Information

Publication History

Received 29 October 1985

Accepted 18 February 1986

Publication Date:
18 July 2018 (online)

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Summary

BRL 26921 is a new acylated streptokinase-plasminogen complex which may have a more specific local thrombolytic effect than streptokinase or urokinase. 34 patients with acute peripheral arterial occlusions were given eight hourly bolus injections of 5 mg BRL 26921 for up to 72 h. Systemic fibrinolysis was observed in all patients yet in only 24% was the occluding thrombus lysed. 44% of the patients had haemorrhagic complications and 24% suffered further thrombotic events during or soon after treatment. There was no correlation between the degree of systemic fibrinolysis produced and dissolution of the thrombi. The degree of systemic fibrinolysis did not affect the complication rate. There is no evidence from this study that BRL 26921 has a specific local thrombolytic effect.

Key words

streptokinase - plasminogen complex - plasminogen complex - Acute peripheral arterial ischaemia - Thrombolysis
 

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