Thromb Haemost 1984; 51(02): 217-221
DOI: 10.1055/s-0038-1661062
Original Article
Schattauer GmbH Stuttgart

The Importance of Corticoids Added to Continued Treatment with Factor VIII Concentrates in the Suppression of Inhibitors in Haemophilia A

J A Aznar
The Servicio de Hematologia y Hemoterapia, Ciudad Sanitaria “LA FE”, Valencia, Spain
,
J I Jorquera
The Servicio de Hematologia y Hemoterapia, Ciudad Sanitaria “LA FE”, Valencia, Spain
,
A Peiró
The Servicio de Hematologia y Hemoterapia, Ciudad Sanitaria “LA FE”, Valencia, Spain
,
I Garcia
The Servicio de Hematologia y Hemoterapia, Ciudad Sanitaria “LA FE”, Valencia, Spain
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 31. Oktober 1983

Accepted 01. Februar 1984

Publikationsdatum:
19. Juli 2018 (online)

Summary

A protocol is presented to suppress inhibitors in haemophilia A using continued treatment with f. VIII (50 U/kg b.w./day) and fluprednisolone (0.5 mg/kg b.w., for 21 days) until reaching correct in vivo recovery after therapeutic administration.

5 high responder patients were treated whose inhibitors were detected at least 2 years before beginning the treatment. The inhibitors were eradicated in 4 patients using continued treatment for between 4 and 24 months. Patient 1 was treated exclusively with factor and the others also with corticoids when the level was 0 B.U. (or 20 B.U., patient 4). The patients began tri-weekly prophylactic treatment and rehabilitation exercises after recovery test normalization. After progressive reduction of the prophylactic treatment they started on demand treatment. After more than 5 months of this treatment no anamnestic response has been detected in any patient, in spite of several factor VIII administrations.

 
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