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Thromb Haemost 1982; 48(03): 250-252
DOI: 10.1055/s-0038-1657272
Original Article
Schattauer GmbH Stuttgart

Acquired Factor XI Deficiency in Systemic Lupus erythematosus

G M Vercellotti
The Hematology Section, Dept. of Medicine, University of Minnesota, Minneapolis, Minnesota, U.S.A.
,
D F Mosher
1   Hematology Section, Dept. of Medicine, University of Wisconsin, Madison, Wis., U.S.A.
› Author Affiliations
Further Information

Publication History

Received 01 July 1982

Accepted 30 August 1982

Publication Date:
13 July 2018 (online)

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Summary

A variety of coagulation abnormalities has been described in systemic lupus erythematosus (SLE). We report a unique SLE patient with an acquired factor XI deficiency. The low factor XI levels were not due to a classical coagulation inhibitor, but to a plasma factor (probably an immunoglobulin) that selectively bound factor XI. The factor XI deficiency improved after treatment with corticosteroids. Thus it is possible that in SLE immune complexes may bind clotting factors making them unavailable for use in the coagulation cascade.

Keywords

Factor XI - Systemic lupus erythematosus
 

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