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Thromb Haemost 1979; 42(05): 1490-1502
DOI: 10.1055/s-0038-1657050
Original Article
Schattauer GmbH Stuttgart

Human Blood Platelet Membrane Glycoproteins

Resolution in Different Polyacrylamide Gel Electrophoretic Systems
C S P Jenkins
The Department of Haematology, University Hospital “Wilhelmina Gasthuis”, Amsterdam, The Netherlands and Theodor Kocher Institute, University of Berne, Berne, Switzerland
,
E F Ali-Briggs
The Department of Haematology, University Hospital “Wilhelmina Gasthuis”, Amsterdam, The Netherlands and Theodor Kocher Institute, University of Berne, Berne, Switzerland
,
G T E Zonneveld
The Department of Haematology, University Hospital “Wilhelmina Gasthuis”, Amsterdam, The Netherlands and Theodor Kocher Institute, University of Berne, Berne, Switzerland
,
A Sturk
The Department of Haematology, University Hospital “Wilhelmina Gasthuis”, Amsterdam, The Netherlands and Theodor Kocher Institute, University of Berne, Berne, Switzerland
,
J Clemetson
The Department of Haematology, University Hospital “Wilhelmina Gasthuis”, Amsterdam, The Netherlands and Theodor Kocher Institute, University of Berne, Berne, Switzerland
› Author Affiliations
Further Information

Publication History

Received 08 May 1979

Accepted 19 June 1979

Publication Date:
23 August 2018 (online)

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Summary

The separation of the major platelet membrane glycoproteins of normal subjects and subjects with well defined platelet membrane glycoprotein abnormalities have been examined using four different polyacrylamide gel electrophoretic techniques (continuous and discontinuous). The mobilities of the resolved glycoprotein bands have been correlated with the glycoprotein nomenclature proposed for the conventional sodium dodecyl sulphate- phosphate buffer system. Since the glycoprotein distribution varies depending on the system used, the merits of each method should be considered before application to a specific problem.

 

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