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Thromb Haemost 1966; 16(01/02): 032-037
DOI: 10.1055/s-0038-1655624
Originalarbeiten — Original Articles — Travaux Originaux
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Arterio-Venous Differences in the Components of the Fibrinolytic Enzyme System[*]

D Ogston
1   Department of Medicine, University of Aberdeen, Aberdeen, Scotland
,
C. M Ogston
1   Department of Medicine, University of Aberdeen, Aberdeen, Scotland
,
N. B Bennett
1   Department of Medicine, University of Aberdeen, Aberdeen, Scotland
› Author Affiliations
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Publication History

Publication Date:
26 June 2018 (online)

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Summary

1. The concentration of the major components of the fibrinolytic enzyme system was compared in venous and arterial blood samples from male subjects.

2. The plasminogen activator concentration was higher in venous blood and the arterio-venous difference increased as its concentration rose, but the ratio of the arterial to venous level remained constant.

3. No arterio-venous difference was found for anti-urokinase activity, antiplasmin, plasminogen and fibrinogen.

4. It is concluded that venous blood determinations of the components of the fibrinolytic enzyme system reflect satisfactorily arterial blood levels.

* This investigation was supported by a grant from the Tobacco Research Council of Great Britain on the recommendation of the British Heart Foundation.


 

  • References

  • 1 Alkjaersig N, Fletcher A. P, Sherry S. The mechanism of clot dissolution by plasmin. J. clin. Invest 38: 1086 1959;
    CrossrefPubMedGoogle Scholar
  • 2 Ghakrabarti R, Birks P. M, Fearnley G. R. Origin of blood fibrinolytic activity from veins and its bearing on the fate of venous thrombi. Lancet I: 1288 1963;
    PubMedGoogle Scholar
  • 3 Clarke R. L, Orandi A, Cliffton E. E. Induction of fibrinolysis by venous obstruction. Angiology 11: 367 1960;
    CrossrefPubMedGoogle Scholar
  • 4 Fearnley G. R, Ferguson J. Arterio-venous differences in natural fibrinolysis. Lancet 11: 1040 1957;
    PubMedGoogle Scholar
  • 5 Fletcher A. P, Biederman O, Moore D, Alkjaersig A, Sherry S. Abnormal plasminogen-plasmin system activity (fibrinolysis) in patients with hepatic cirrhosis: its cause and consequences. J. clin. Invest 43: 681 1964;
    CrossrefPubMedGoogle Scholar
  • 6 Naimi S, Goldstein R, Proger S. Studies of coagulation and fibrinolysis of the arterial and venous blood in normal subjects and patients with atherosclerosis. Circulation 27: 904 1963;
    CrossrefPubMedGoogle Scholar
  • 7 Nilsson I. M, Olow B. Fibrinolysis induced by streptokinase in man. Acta chir. scand 123: 247 1962;
    PubMedGoogle Scholar
  • 8 Ratnojf O. D, Menzie G. A new method for the determination of fibrinogen in small samples of plasma. J. Lab. clin. Med 37: 316 1951;
    PubMedGoogle Scholar
  • 9 Remmert L. F, Cohen P. Partial purification and properties of a proteolytic enzyme of human serum. J. biol. Chem 181: 431 1949;
    PubMedGoogle Scholar
  • 10 Sherry S, Lindemeyer R. I, Fletcher A. P, Alkjaersig N. Studies on enhanced fibrinolytic activity in man. J. clin. Invest 38: 810 1959;
    CrossrefPubMedGoogle Scholar
  • 11 Tighe J. R, Swan H. T. Fibrinolysis and venous obstruction. Clin. Sci 25: 219 1963;
    PubMedGoogle Scholar
  • 12 Todd A. S. Localisation of fibrinolytic activity in tissues. Brit. med. Bull 20: 210 1964;
    CrossrefPubMedGoogle Scholar