Download PDF
Hamostaseologie 1986; 06(04): 170-179
DOI: 10.1055/s-0038-1655156
Originalarbeiten
Schattauer GmbH

Thrombolysetherapie beim akuten Herzinfarkt

M. von Eiff
1   Medizinischen Klinik und Poliklinik der Universität Münster
,
J. van de Loo
1   Medizinischen Klinik und Poliklinik der Universität Münster
› Author Affiliations
Further Information

Publication History

Publication Date:
25 June 2018 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Thrombolytische Therapie von Patienten mit frischem Herzinfarkt führt in über der Hälfte der Fälle zu einer frühen Rekanalisation des thrombotisch verschlossenen Infarktgefäßes. Intravenös verabreichter Gewebeplasminogenaktivator ist vergleichbar wirksam wie intrakoronar infundierte Streptokinase oder Urokinase. Prourokinase und acylierte Streptokinase sind neue Thrombolytika, deren Wirksamkeit bisher noch nicht ausreichend zu beurteilen ist. Risikopatienten, d. h. Patienten in höherem Alter, mit primär erniedrigter linksventrikulärer Herzfunktion und mit Zweitinfarkt scheinen besonders von der thrombolytischen Therapie zu profitieren. Entscheidend für die Prognose des Patienten ist ein möglichst frühzeitiges Einsetzen der Therapie, um reversibel geschädigtes Myokard zu retten.

Ungelöste Probleme sind die relativ hohen Raten früher Reokklusion nach i.e. SK und nach i.v. t-PA sowie die unklare Bedeutung der systemischen Aktivierung des fibrinolytischen Systems.

Die intravenöse Infusion eines Thrombolytikums ist in jedem Krankenhaus möglich. Die Entscheidung über eine invasive Weiterbehandlung mittels transluminaler koronarer Angioplastie bzw. eines aortokoronaren Bypass sollte danach unverzüglich in einem spezialisierten Zentrum herbeigeführt werden.

 

  • LITERATUR

  • 1 Alderman EL, Jutzy KR. et al. Randomized comparison of intravenous versus intracoronary streptokinase for myocardial infarction. Am J Cardiol 1984; 54: 14-9.
    PubMedGoogle Scholar
  • 2 Aldor E, Kainz W. Ventrikelfunktion nach erfolgreicher und erfolgloser systemischer Fibrinolyse bei frischem Myokardinfarkt. Herz/Kreislauf 1984; 02: 59-64.
    PubMedGoogle Scholar
  • 3 Anderson JL, Marshall HW. et al. A randomized trial of intracoronary streptokinase in the treatment of acute myocardial infarction. N Engl J Med 1983; 308: 1312-8.
    CrossrefPubMedGoogle Scholar
  • 4 Anderson JL, Marshall HW. et al. A randomized trial of intravenous and intracoronary streptokinase in patients with acute myocardial infarction. Circulation 1984; 70: 606-18.
    CrossrefPubMedGoogle Scholar
  • 5 Benda L, Klösel W. et al. Fibrinolyse bei akutem Herzinfarkt mit erhöhtem Risiko. Wien Z Inn Med 1973; 54: 454-65.
    PubMedGoogle Scholar
  • 6 Bett JHN, Castaldi PA. et al. Australian Multicentre Trial of Streptokinase in acute myocardial infarction. Lancet 1973; I: 57-60.
    PubMedGoogle Scholar
  • 7 Braunwald E, Kloner RA. The stunned myocardium: prolonged, post ischemic ventricular dysfunction. Circulation 1982; 66: 1146-9.
    CrossrefPubMedGoogle Scholar
  • 8 Collen D, Topol EJ. et al. Coronary thrombolysis with recombinant human tissue plasminogen activator: a prospective, randomized, placebo-controlled trial. Circulation 1984; 70: 1012-7.
    CrossrefPubMedGoogle Scholar
  • 9 Corday E, Meerbaum S. Introduction: Symposion on the present status of reperfusion of the acutely ischemic myocardium, Part I. J Am Coll Cardiol 1983; 01: 1031-6.
    CrossrefPubMedGoogle Scholar
  • 10 De Coster PM, Melin JA. et al. Coronary artery reperfusion in acute myocardial infarction: assessment by preand postintervention Thallium-201 myocardial perfusion imaging. Am J Cardiol 1985; 55: 889-95.
    CrossrefPubMedGoogle Scholar
  • 11 Cowley ML, Gold HK. Use of intracoronary streptokinase in acute myocardial infarction. Mod Concepts Cardiovasc Dis 1982; 51: 97-102.
    PubMedGoogle Scholar
  • 12 Cowley MJ, Hastillo A. et al. Fibrinolytic effects of intracoronary streptokinase administration in patients with acute myocardial infarction and coronary insufficiency. Circulation 1983; 67: 1031-8.
    CrossrefPubMedGoogle Scholar
  • 13 Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med 1984; 310: 1137-40.
    CrossrefPubMedGoogle Scholar
  • 14 Eigler N, Maurer G. et al. Effect of early systemic thrombolytic therapy of left ventricular mural thrombus formation in acute anterior myocardial infarction. Am J Cardiol 1984; 54: 261-3.
    CrossrefPubMedGoogle Scholar
  • 15 v. Essen R, Uebis R. et al. Intracoronare Streptokinase beim akuten Herzinfarkt. Dtsch med Wschr 1985; 110: 570-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 European Cooperative Study Group. Streptokinase in acute myocardial infarction. N Engl J Med 1979; 301: 797-802.
    CrossrefPubMedGoogle Scholar
  • 17 European Cooperative Study Group for recombinant tissue-type plasminogen activator. Randomized trial of intravenous recombinant tissue-type-plasminogen-activator versus intravenous streptokinase in acute myocardial infarction. Lancet 1985; 05: 842-7.
    PubMedGoogle Scholar
  • 18 Falk E. Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Circulation 1985; 71: 699-708.
    CrossrefPubMedGoogle Scholar
  • 19 Ferguson DW, White CW. et al. Influence of baseline ejection fraction and success of thrombolysis on mortality and ventricular function after myocardial infarction. Am J Cardiol 1984; 54: 705-11.
    CrossrefPubMedGoogle Scholar
  • 20 De Feyter PJ. van Eenige et al. Effects of spontaneous and streptokinase-induced recanalisation of left ventricular function after myocardial infarction. Circulation 1983; 67: 1039-44.
    CrossrefPubMedGoogle Scholar
  • 21 Fischer EJ, Nell J. et al. Die fibrinolytische Frühbehandlung des akuten Herzinfarktes. Med Welt 1979; 30: 1567-74.
    PubMedGoogle Scholar
  • 22 Fischer EJ. Einfluß der fibrinolytischen Frühbehandlung auf den Therapieerfolg beim transmuralen Herzinfarkt. Therapiewoche 1981; 31: 2556-68.
    PubMedGoogle Scholar
  • 23 Fischer EJ, Nell J, Bormes J. 20 Jahre systemische Frühfibrinolyse des transmuralen Myokardinfarktes (Ergebnisbericht über 550 Fälle). In: Trübestein G, Etzel F. (Hrsg). Fibrinolytische Therapie. Stuttgart: Schattauer; 1983: 415-24.
    Google Scholar
  • 24 Ganz W, Buchbinder N. et al. Intracoronary thrombolysis in evolving myocardial infarction. Am Heart J 1981; 101: 4-13.
    CrossrefPubMedGoogle Scholar
  • 25 Ganz W, Geft J. et al. Intravenous streptokinase in evolving acute myocardial infarction. Am J Cardiol 1984; 53: 1209-16.
    CrossrefPubMedGoogle Scholar
  • 26 Gordon RJ, Suyder GK. et al. Potential significance of plasma viscosity and hematocrit variations in myocardial ischemia. Am Heart J 1974; 87: 175-82.
    CrossrefPubMedGoogle Scholar
  • 27 Harrison DG, Ferguson DW. et al. Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesions. Circulation 1984; 69: 991-9.
    CrossrefPubMedGoogle Scholar
  • 28 Karsch K, Blanke H. et al. Changes in the degree of stenosis of the infarct vessel following intracoronary streptokinase (Abstr). Circulation 1981; Suppl IV: IV-107.
    PubMedGoogle Scholar
  • 29 Karsch KR, Hofmann M. Thrombolysis in acute experimental myocardial infarction. J Am Coll Cardiol 1983; 01: 427-35.
    CrossrefPubMedGoogle Scholar
  • 30 Kennedy JW, Gensini GG. et al. Acute myocardial infarction treated with intracoronary streptokinase: A report of the society for cardiac angiography. Am J Cardiol 1985; 55: 871-7.
    CrossrefPubMedGoogle Scholar
  • 31 Kennedy JW, Ritchie JL. et al. The Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 1983; 309: 1477-81 N Engl J Med 1985; 312: 1073-78.
    CrossrefPubMedGoogle Scholar
  • 32 Khaja F, Walton JA. et al. Intracoronary fibrinolytic therapy in acute myocardial infarction. Report of a prospective randomized trial. N Engl J Med 1983; 308: 1305-11.
    CrossrefPubMedGoogle Scholar
  • 33 Köstering H, Rentrop P, Blanke H, Kaiser H, Ganasinski J, Tebbe U, Schrader J, Neuhaus KL. Blutgerinnungsveränderungen unter der Streptokinase-Behandlung bei Patienten mit akutem Myokardinfarkt. In: Trübestein G, Etzel F. (Hrsg). Fibrinolytische Therapie. Stuttgart: Schattauer; 1983: 435-46.
    Google Scholar
  • 34 Köstering H, Tebbe U, Kaiser H, Thiemann U, Neuhaus KL. Aktivierung der Fibrinolyse und Blutgerinnungsveränderungen unter einer hochdosierten Kurzzeit-Streptokinasebehandlung bei Patienten mit akutem Myokardinfarkt. In: Trübestein G, Etzel F. (Hrsg). Fibrinolytische Therapie. Stuttgart: Schattauer; 1983: 447-53.
    Google Scholar
  • 35 Koren G, Weiss A. et al. Prevention of myocardial damage in acute myocardial ischemia by early treatment with intravenous streptokinase. N Engl J Med 1985; 313: 1384-9.
    CrossrefPubMedGoogle Scholar
  • 36 Lee G, Joye JA. et al. Determinants of beneficial coronary streptokinase therapy in acute myocardial infarction: success and rapidity of thrombolysis depends on minimal time from symptom onset to treatment (abstr). Am J Cardiol 1982; 49: 973.
    PubMedGoogle Scholar
  • 37 Leiboff RH, Katz RJ. et al. A randomized, angiographically controlled trial of intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1984; 53: 404.
    CrossrefPubMedGoogle Scholar
  • 38 Maddahi J, Ganz W. et al. Myocardial salvage by intracoronary thrombolysis in evolving acute myocardial infarction. Evaluation using intracoronary injection of Thallium-201. Am Heart J 1981; 102: 664.
    CrossrefPubMedGoogle Scholar
  • 39 Markis JE, Malagold M. et al. Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction. Assessment by intracoronary Thallium-201. N Eng J Med 1981; 305: 777-82.
    CrossrefPubMedGoogle Scholar
  • 40 Mathey D, Schofer J, Stritzke P, Montz R, Krebber HJ, Tilsner V, Bleifeld W. Intracoronare Thrombolyse-Therapie beim akuten Herzinfarkt. Hämostaseologie 1983; 03: 29-37.
    PubMedGoogle Scholar
  • 41 Mathey DG, Schofer J. et al. Intravenous urokinase in acute myocardial infarction. Am J Cardiol 1985; 55: 878-82.
    CrossrefPubMedGoogle Scholar
  • 42 Merx W, Doerr R. et al. Evaluation of the effectiveness of intracoronary streptokinase infusion in acute myocardial infarction : postprocedure management and hospital course in 204 patients. Am Heart J 1981; 102: 1181-7.
    CrossrefPubMedGoogle Scholar
  • 43 Meyer J, Erbel R. et al. PTCA und intracoronare Lyse bei akutem Myokardinfarkt. 52. Jahrestagung der Deutschen Gesellschaft für Herzund Kreislaufforschung. Kardiologie. 1986 75. Suppl I, 53 (Abstr).
    PubMedGoogle Scholar
  • 44 Neuhaus KL, Köstering H. et al. Intravenöse Kurzzeitstreptokinase-Therapie beim frischen Myocardinfarkt. Z Kardiol 1981; 70: 791.
    PubMedGoogle Scholar
  • 45 Kreuzer H, Sauer G, Thiemann U, Köstering H, Neuhaus KL, Tebbe U. Intravenöse Streptokinase-Kurzinfusion beim akuten Myokardinfarkt. Hämostaseologie 1983; 03: 38-43.
    PubMedGoogle Scholar
  • 46 Neuhof H, Hey D. et al. Hemodynamic reactions induced by streptokinase therapy in patients with acute myocardial infarction. Europ J Intens Care Med 1975; 01: 27-30.
    PubMedGoogle Scholar
  • 47 v. Olshausen K, Zimmermann R, Harenberg J, Schwarz F, Kandier D, Rebmann T, Kübler W. The impact of heparin and acetylsalicyclic acid on success rate and sideeffects of intracoronary fibrinolysis. In: Trübestein G, Etzel F. (Hrsg). Fibrinolytische Therapie. Stuttgart: Schattauer; 1983: 569-72.
    Google Scholar
  • 48 Oison HG, Lyons KP. et al. A randomized controlled trial of intravenous streptokinase in acute myocardial infarction (Abst). Circulation 1984; 11-155.
    PubMedGoogle Scholar
  • 49 Ong L, Reiser P. et al. Left ventricular function and rapid release of creatine kinase MB in acute myocardial infarction: evidence for spontaneous reperfusion. N Engl J Med 1983; 309: 1-6.
    CrossrefPubMedGoogle Scholar
  • 50 Raizner AE, Tortoledo FA. et al. Intracoronary thrombolytic therapy in acute myocardial infarction: A prospective, randomized, controlled trial. Am J Cardiol 1985; 55: 301-8.
    CrossrefPubMedGoogle Scholar
  • 51 Reduto LA, Freund GC. et al. Coronary artery reperfusion in acute myocardial infarction : beneficial effects of intracoronary streptokinase on left ventricular salvage and performance. Am Heart J 1981; 102: 1168-77.
    CrossrefPubMedGoogle Scholar
  • 52 Reimer KA, Lowe JE. et al. The wavefront phenomen of ischemic cell death ; myocardial infarction size vs duration of coronary occlusion in dogs. Circulation 1977; 56: 785-99.
    PubMedGoogle Scholar
  • 53 Rentrop P. New York multicenter trial : intracoronary lysis (Streptokinase) Internationaler Workshop : Coronary Artery Disease, München. 1986
    PubMedGoogle Scholar
  • 54 Rentrop P, Blanke H. Thrombolytische Therapie beim akuten Myokardinfarkt. Dtsch med Wschr 1985; 110: 885-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 55 Rentrop KP, Feit F. et al. Effects of intracoronary streptokinase and intracoronary nitroglycerin infusion on coronary angiographic patterns and mortality in patients with acute myocardial infarction. N Engl J Med 1984; 311: 1457-63.
    CrossrefPubMedGoogle Scholar
  • 56 Research Commitee on Coronary Thrombolysis. Treatment of acute myocardial infarction with intracoronary urokinase infusion: preliminary results of 242 cases from 15 medical centers in Japan (Abstr). Jpn Cire J 1984; 47: 900.
    PubMedGoogle Scholar
  • 57 Ritchie JL, Davies KB. et al. Global and regional left ventricular function and tomographic radionuclid perfusion : The Western Washington intracoronary streptokinase in myocardial infarction trial. Circulation 1984; 70: 867-75.
    CrossrefPubMedGoogle Scholar
  • 58 Rogers W, Baxley WA. et al. Return of LV function following reperfusion in myocardial infarction importance of subtotal stenoses or intact collaterals. J Am Coll Cardiol 1983; 01: 629.
    PubMedGoogle Scholar
  • 59 Rogers WJ, Mautle JA. et al. Prospective randomized trial of intravenous and intracoronary streptokinase in acute myocardial infarction. Circulation 1983; 68: 1051-61.
    CrossrefPubMedGoogle Scholar
  • 60 Rothbard RL, Fitzpatrick PG. et al. Relationship of the lytic state to successful reperfusion with standardand low-dose intracoronary streptokinase. Circulation 1985; 71: 562-70.
    CrossrefPubMedGoogle Scholar
  • 61 Schaper W, Pasyk S. Influence of collateral flow on the ischemic tolerance of the heart following acute and sub acute coronary occlusion. Circulation 1976; 53 (Suppl I): 157-162.
    CrossrefPubMedGoogle Scholar
  • 62 Schaper J, Schaper W. Reperfusion of ischemic myocardium: Ultrastructural and histochemical aspects. J Am Coll Cardiol 1983; 01: 1037-46.
    CrossrefPubMedGoogle Scholar
  • 63 Schmutzler R, Fritze E, Gebauer D, Gillmann H, Heckner F, Körtge P, van de Loo J, Pezold FA, Poliwoda H, Praetorius F, Zekorn D. Fibrinolytic therapy in acute myocardiol infarction. 2nd German-Swiss Cooperative Study. In: Mammen EF, Anderson GF, Barnhart MJ. Eds. Thrombolytic Therapy. Transactions of the Nineteenth Annual Symposium on Blood. Stuttgart: Schattauer; 1971: 211-6.
    Google Scholar
  • 64 Schröder R. Intracoronare versus systemische Thrombolyse. Internist 1983; 24: 396-401.
    PubMedGoogle Scholar
  • 65 Schröder R. Multicenter trial : intravenous lysis (Streptokinase) ISAM. Internationaler Workshop : Coronary Artery Disease, München. 1986
    PubMedGoogle Scholar
  • 66 Schröder R. Intravenöse Thrombolyse bei akutem Myokardinfarkt. 52. Jahrestagung der Deutschen Gesellschaft für Herzund Kreislaufforschung. Kardiologie. 1986 75. (Suppl 1): 53 (Abstr).
    PubMedGoogle Scholar
  • 67 Schröder R, Biamino G. et al. Systemische Thrombolyse mit Streptokinase-Kurzzeitinfusion bei akutem Myokardinfarkt. Z Kardiol 1982; 71: 709.
    PubMedGoogle Scholar
  • 68 Schröder R, Vöhringer H. et al. Follow-up after coronary arterial reperfusion with intravenous streptokinase in relation to residual myocardial infarct artery narrowing. Am J Cardiol 1985; 55: 313-7.
    CrossrefPubMedGoogle Scholar
  • 69 Schuler G, Schwarz F. et al. Thrombolysis in acute myocardial infarction using intracoronary streptokinase. Assessment by Thallium-201, Scintigraphy. Circulation 1982; 66: 658-64.
    CrossrefPubMedGoogle Scholar
  • 70 Schwarz F, Kübler W. Thrombolytische Therapie des akuten Herzinfarktes. Internist 1984; 25: 713-20.
    PubMedGoogle Scholar
  • 71 Schwarz F, Schuler G. et al. Intracoronary thrombolysis in acute myocardial infarction: Correlations among serum enzyme, scintigraphic and hemodynamic findings. Am J Cardiol 1982; 50: 32.
    CrossrefPubMedGoogle Scholar
  • 72 Serruys PW, Wijns W. et al. Is transluminal coronary angioplasty mandatory after successful thrombolysis?. Br Heart J 1983; 50: 257-65.
    CrossrefPubMedGoogle Scholar
  • 73 Sobel BE, Geltman E. et al. Improvement of regional myocardial metabolism after coronary thrombolysis induced with tissuetype plasminogen activator or streptokinase. Circulation 1984; 69: 983-90.
    CrossrefPubMedGoogle Scholar
  • 74 Spann JF, Sherry S. et al. Coronary thrombolysis by intravenous streptokinase in acute myocardial infarction : acute and follow-up studies. Am J Cardiol 1984; 53: 655-61.
    CrossrefPubMedGoogle Scholar
  • 75 Stampfer MJ, Goldhaber SZ. et al. Effect of intravenous streptokinase on acute myocardial infarction. N Engl J Med 1982; 307: 1180-2.
    CrossrefPubMedGoogle Scholar
  • 76 Taylor GJ, Mikell FL. et al. Intravenous versus intracoronary streptokinase therapy for acute myocardial infarction in community hospitals. Am J Cardiol 1984; 54: 256-60.
    CrossrefPubMedGoogle Scholar
  • 77 Tendera MP, Campbell WB. et al. Factors influencing probability of reperfusion with intracoronary ostial infusion of thrombolytic agent in patients with acute myocardial infarction. Circulation 1985; 71: 124-8.
    CrossrefPubMedGoogle Scholar
  • 78 Tennant SN, Dixon J. et al. Intracoronary thrombolysis in acute myocardial infarction: comparison of the efficacy of urokinase to streptokinase. Circulation 1984; 69: 756-60.
    CrossrefPubMedGoogle Scholar
  • 79 Theiss W. Das hämostatische System während intrakoronarer und intravenöser Fibrinolysetherapie des Herzinfarktes. Fibrinolyse-Symposion, Münster 84. Berlin Heidelberg New York: Springer; (in Druck).
    Google Scholar
  • 80 Theiss W, Wirtzfeld A. Coagulation studies and rheological considerations in a subsample of patients pertaining to the European Trial of streptokinase in acute myocardial infarction. Act Med Scand Suppl 1981; 648: 97-104.
    PubMedGoogle Scholar
  • 81 Thrombolysis in myocardial infarction (TIMI). N Engl J Med. 1985 312. 915-6 932-6..
    PubMedGoogle Scholar
  • 82 Tiefenbrunn AJ, Robison AK. et al. Clinical pharmacology in patients with evolving myocardial infarction of tissuetype plasminogen activator produced by recombinant DNA technology. Circulation 1985; 71: 110-6.
    CrossrefPubMedGoogle Scholar
  • 83 Timmis GC, Gangadharan V. et al. Hemorrhage and the products of fibrinogen digestion after intracoronary administration of streptokinase. Circulation 1984; 69: 1146-52.
    CrossrefPubMedGoogle Scholar
  • 84 Gruppo Italiano per lo Studio della Streptochinasi nelF Infarto Miocardico (GISSI): Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986; I: 397-401.
    PubMedGoogle Scholar
  • 85 Valentine RP, Pitts DE. et al. Intravenous versus intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1985; 55: 309-12.
    CrossrefPubMedGoogle Scholar
  • 86 Van De Werf F, Ludbrook PA. et al. Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardiol infarction. N Engl J Med 1984; 310: 609-13.
    CrossrefPubMedGoogle Scholar
  • 87 Verheugt FW, van Eenige MJ. et al. Bleeding complications of intracoronary streptokinase: Assessment of risk in a randomized trial (Abstr). Circulation 1984; Suppl II 11-29.
    PubMedGoogle Scholar
  • 88 Verstraete M, Bory M. et al. Randomized trial of intravenous recombinanant tissuetype plasminogen activator versus intravenous streptokinase in acute myocardial infarction. Lancet 1985; 842-7.
    PubMedGoogle Scholar
  • 89 Verstraete M, Brower RW. et al. Double blind randomized trial of intravenous tissue type plasminogen activator versus placebo in acute myocardial infarction. Lancet 1985; II: 965-9.
    PubMedGoogle Scholar
  • 90 Volger E, Theiss E. Rheological consequences of systemic streptokinase therapy in acute myocardial infarction. In: Trübestein G, Etzel F. Hrsg. Fibrinolytische Therapie. Stuttgart: Schattauer; 1983: 455-62.
    Google Scholar
  • 91 White CW, Schwartz JL. Systemic markers of fibrinolysis after unsuccessful intracoronary streptokinase thrombolysis for acute myocardiol infarction. Am J Cardiol 1984; 54: 712-7.
    CrossrefPubMedGoogle Scholar
  • 92 Wiliams DO. Intravenous recombinant tissue type plasminogen activator (r-tPA) in acute myocardial infarction. J Am Coll Cardiol 1985; 05: 495.
    PubMedGoogle Scholar
  • 93 De Wood MA, Spores J. et al. Prevalence of total coronary occlusion during the early hours of transmural moycardial infarction. N Engl J Med 1980; 303: 897-902.
    CrossrefPubMedGoogle Scholar
  • 94 Yasuno M, Saito Y. et al. Effects of percutaneous transluminal coronary angioplasty: intracoronary thrombolysis with urokinase in acute myocardial infarction. Am J Cardiol 1984; 53: 1217-20.
    CrossrefPubMedGoogle Scholar
  • 95 Yusuf S, Collins R. et al. Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J 1985; 06: 556-85.
    CrossrefPubMedGoogle Scholar