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Thromb Haemost 1960; 4(02): 196-200
DOI: 10.1055/s-0038-1654496
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis[*]

E. A Loeliger
1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
,
B. v. d Esch
1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
,
C. Ch ter Haar Romeny-Wachter
1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
,
H. L Booij
1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
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Publikationsverlauf

Publikationsdatum:
17. Juni 2018 (online)

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Summary

The range of the hourly turnover rate of factor VII, found in 17 normal individuals, 14 patients with thrombo-embolic diseases and 3 patients with congential hypoproconvertinaemia, was 11.1—16.6% of the total body pool of factor VII (mean normal value 13.8%). The possible significance of this rapid turnover rate of factor VII in prophylactic anticoagulant treatment with 4-hydroxycoumarin derivatives is stressed.

* This investigation was supported by the Netherlands Organization for Applied Scientific Research (T.N.O.).


 

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