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Thromb Haemost 1967; 17(01/02): 156-164
DOI: 10.1055/s-0038-1654090
Originalarbeiten - Original Articles - Travaux Originaux
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Studies on the Pathogenesis of the Generalized Shwartzman Reaction

IV: Production of a Shwartzman-like phenomenon with autoprothrombin-C
F Rodríguez-Erdmann   *
1   New England Medical Center Hospitals and Department of Medicine, Tufts -University School of Medicine, Boston
,
S Naimi
1   New England Medical Center Hospitals and Department of Medicine, Tufts -University School of Medicine, Boston
› Author AffiliationsSupported by Res. Grant HE-03753 from Nat. Inst. Health, Bethesda, Md., and a training grant from Nat. Heart Inst. (5 Tl-He-5391).
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Publication History

Publication Date:
26 June 2018 (online)

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Summary

Autoprothrombin-C (factor Xa) was given intravenously to rabbits whose RES had been previously blocked with thorotrast. The coagulo-analytical results as well as the morphological changes resemble those of the classical generalized Shwartzman reaction (gSr) produced by properly spaced doses of Gram-negative endotoxin. The results are discussed in the light of the literature.

* Reprint requests to 5 & 6 Medical Services, Boston City Hospital, Boston, 02118, USA.


 

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