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Thromb Haemost 1971; 26(02): 370-377
DOI: 10.1055/s-0038-1653685
Originalarbeiten – Original Articles – Travaux Originaux
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The Human Blood Platelets as a Molecular Mosaic Its Role in Aggregation and Thrombus Formation[*]

J. N Mehrishi   **
1   Department of Radiotherapeutics, University of Cambridge, Addenbrook’s Hospital, Trumpington Street, Cambridge, England
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

On the surface of human blood platelets various types of groups are present - sulphydryl groups, positively charged amino groups and at least three types of anionogenic groups. The numbers of these groups on a per cell basis have been calculated and then* relative contributions to the net charge determined. Two arrangements for the distribution of the groups in the cell periphery have been proposed. Such studies provide a molecular basis for many reactions taking place at the cell surface. The role of these groups in platelet aggregation and thrombus formation is discussed

* Based on a lecture delivered to the British Microcirculation Society.


** Present address : Max-Planck-Institut für Biochemie, Munich, Germany.


 

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