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Thromb Haemost 1981; 46(03): 602-603
DOI: 10.1055/s-0038-1653427
Original Article
Schattauer GmbH Stuttgart

The Effect of Partial Splenectomy on Platelet Production in Mice

H Bessler
The Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel Aviv University Medical School, Israel
,
I Notti
The Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel Aviv University Medical School, Israel
,
M Djaldetti
The Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel Aviv University Medical School, Israel
› Author Affiliations
Further Information

Publication History

Received 16 October 1980

Accepted 09 July 1981

Publication Date:
26 July 2018 (online)

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Summary

The effect of total and partial splenectomy on the number and production of circulating platelets was studied in mice. Five days after total and partial splenectomy the number of the peripheral blood platelets increased by 87% and 60%, respectively and the incorporation of 75selenium methionine (75Se-Met) into platelets was enhanced indicating that the thrombocytosis was due to increased platelet production. The results obtained by the two operative procedures were compared.

Since previous work from our laboratory has shown that a factor produced by splenic lymphocytes affects the platelet number in mice, it is suggested that the differences in the number of circulating platelets observed in animals after total and partial splenectomy may reflect a difference in the number of spleen lymphocytes removed.

Keywords

Partial splenectomy - Platelets - Thrombocytosis
 

  • References

  • 1 Kotilainen M. Platelet kinetics in normal subjects and haematological disorders with special reference to thrombocytopenia, and the role of the spleen. Scand J Haematol 1969; Suppl 5
    PubMedGoogle Scholar
  • 2 Najean Y, Ardaillou N, Caen J, Larrieu M-J, Bernard J. Survival of radiochromium-labeled platelets in thrombocytopenias. Blood 1963; 22: 718-732
    PubMedGoogle Scholar
  • 3 Baldini M. Idiopathic thrombocytopenic parpura. N Engl J Med 1966; 274: 1245-1251
    CrossrefPubMedGoogle Scholar
  • 4 Baldini M. Idiopathic thrombocytopenic purpura. N Engl J Med 1966; 274: 1360-1367
    CrossrefPubMedGoogle Scholar
  • 5 Harker LA. Thrombokinetics in idiopathic thrombocytopenic purpura. Br J Haematol 1970; 19: 95-99
    CrossrefPubMedGoogle Scholar
  • 6 Bessler H, Mandel EM, Djaldetti M. Role of the spleen and lymphocytes in regulation of the circulating platelet number in mice. J Lab Clin Med 1978; 91: 760-768
    PubMedGoogle Scholar
  • 7 Penington DG. Assessment of platelet production with 75Se selenomethionine. Br Med J 1969; 4: 782-784
    CrossrefPubMedGoogle Scholar
  • 8 Rak K. Effect of vincristine on platelet production in mice. Br J Haematol 1972; 22: 617-624
    CrossrefPubMedGoogle Scholar
  • 9 Karpatkin S, Strick N, Siskind GW. Detection of splenic anti-platelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). Br J Haematol 1972; 23: 167-176
    PubMedGoogle Scholar