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Thromb Haemost 1968; 20(03/04): 588-595
DOI: 10.1055/s-0038-1651302
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Initial Studies of a Potent Antiheparin Agent (Ubiquin®)

[oligo-3-(N-methylmorpholinium)-1,2-propylene oxide chloride]
E. B Goodsell
1   Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois, U.S.A.
,
R. A Krause
1   Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois, U.S.A.
,
E. T Kimura
1   Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois, U.S.A.
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Ubiquin (oligo-3-(N-methylmorpholinium)-l,2-propylene oxide chloride) is a stable, water soluble, active heparin antagonist producing prompt neutralization when administered in a 1:1 ratio to rats and dogs. Initial studies indicate that it is devoid of any effect on coagulation per se; nor are there any obvious side effects manifested during the process of neutralization. The acute toxicity is less than that of other compounds in use: toluidine blue, protamine and hexadimethrine.

 

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