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Thromb Haemost 1968; 20(01/02): 257-266
DOI: 10.1055/s-0038-1651265
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Inhibition by Dipyridamole of Arterial Thrombosis in Rats

Paul Didisheim M. D.
1   Section of Clinical Pathology, Mayo Clinic, Rochester, Minnesota
› Author AffiliationsThis work was supported in part by Research Grant HE-9863 from the National Institutes of Health and by a grant from the Minnesota Heart Association.
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Thrombi in mesenteric arteries of the rat were produced by electric means. The effectiveness of 4 agents – heparin, aspirin, warfarin, and dipyridamole – in modifying arterial thrombosis was examined with this model. Heparin and aspirin had equivocal beneficial effects. Warfarin had a deleterious effect: the duration of complete occlusion was prolonged. In striking contrast, dipyridamole induced a marked shortening in the duration of complete thrombotic occlusion. On reinjection of the drug, occlusion was almost completely suppressed.

 

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