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Thromb Haemost 1966; 15(01/02): 231-237
DOI: 10.1055/s-0038-1649424
Originalarbeiten — Original Articles — Travaux Originaux
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Comparative Research on the Fibrinolytic Action of Different Nicotinic Acid Derivatives Following Their Prolonged Administration into Rabbits

P de Nicola
1   Clinica Medica, University of Pavia, Italy (Director: Prof. P. Introzzi)
,
A Gibelli
1   Clinica Medica, University of Pavia, Italy (Director: Prof. P. Introzzi)
,
G Turazza
1   Clinica Medica, University of Pavia, Italy (Director: Prof. P. Introzzi)
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Six different nicotinic acid derivatives were given intravenously into rabbits for 28 days. The dosage was calculated on the basis of equivalents of nicotinic acid. Fibrinolytic activity in plasma was studied by means of the fibrin plate method (heated plates; euglobulinic precipitate, with and without the addition of activator). Plasmin and plasminogen activities were evaluated. The most significant results concern the differences in duration, intensity and type (plasmin and/or plasminogen increase) of effect of the different nicotinic acid derivatives.

 

  • References

  • 1 Astrwp T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem 40: 346 1952;
    CrossrefPubMedGoogle Scholar
  • 2 Belle M. Oral nicotinic acid for hyperlipemia with emphasis on side effects. Amer. J. Cardiol 02: 449 1958;
    CrossrefPubMedGoogle Scholar
  • 3 Berge K. G. Hypercholesteremia and nicotinic acid. Amer. J. Med 31: 24 1961;
    CrossrefPubMedGoogle Scholar
  • 4 de Nicola P. Critical evaluation of methods for the study of blood coagulation, fibrinolysis and hemostasis. Thromb. Diath. Haemorrh. (Suppl. 01) ad Vol. 07: 325 1962;
    PubMedGoogle Scholar
  • 5 de Nicola P, Frandoli G, Gibelli A. Attivazione della fibrinolisi da somministrazione prolungata per via orale di un derivato nicotinico in soggetti arteriosclerotici. G. Geront 11: 955 1963;
    PubMedGoogle Scholar
  • 6 de Nicola P, Gibelli A, Frandoli G. The role of indirect fibrinolytic agents in thrombolytic therapy: fibrinolytic activity of a new nicotinic acid derivative following prolonged oral administration. Proc. 9th Congr. Europ. Soc. Haemat. 1394 Lisbon 1963, Karger; Basel/ New York: 1963
    Google Scholar
  • 7 de Nicola P, Sacchetti G, Gibelli A. Erfahrungen mit der Fibrinolyse durch Nikotinsäure und Nikotinsäurederivate. Thromb. Diathes. haemorrh. (Stuttg.). (Suppl. 03) ad Vol. 07: 173 1963;
    PubMedGoogle Scholar
  • 8 de Nicola P, Soardi F. Studio fisiopatologico e clinico della fibrinolisi con il metodo delle piastre difibrina. Quad. Coagul. 7 1960;
    PubMedGoogle Scholar
  • 9 Egli H, Klensch H. Zur Fibrinolyse und Kreislauf Wirkung der Nikotinsäure unter besonderer Berücksichtigung ihrer therapeutischen Anwendbarkeit. Med. Welt (Stuttg.) 1961; 2108.
    PubMedGoogle Scholar
  • 10 Frandoli G, Gibelli A, Turazza G. II nicotinato di betaina nella terapia fibrinolitica prolungata per via orale. Gazz. int. Med. Chir 68: 2065 1964;
    PubMedGoogle Scholar
  • 11 Holemans R. Enhancing the fibrinolytic activity of the blood by vasoactive drugs. Med. exp 09: 5 1963;
    PubMedGoogle Scholar
  • 12 Pardue W. O. Severe liver dysfunction during nicotinic acid therapy. J.A.M.A 175: 137 1961;
    CrossrefPubMedGoogle Scholar
  • 13 Rivins A. U. Jaundice occurring during nicotinic acid therapy for hypercholesteremia. J.A.M.A 170: 2088 1959;
    CrossrefPubMedGoogle Scholar
  • 14 Samama M. Activité fibrinolytique par le nicotinate de théophilline. Yerh. II. Internat. Gespräche über Angiologie 1962. Kreislauf-Bücherei, Bd. 21. 228 Steinkopff. Darmstadt: 1963
    PubMedGoogle Scholar
  • 15 Schwick P. Beiträge zur Diagnostik von Gerinnungsstörungen. Laboratoriums-Blätter für die medizinische Diagnostik 01: 1-108 1961;
    PubMedGoogle Scholar
  • 16 Voss D. Beta-Pyridyl-carbinol und Fibrinolyse. Med. Welt (Stuttg.). 1963 2700
    PubMedGoogle Scholar