Thromb Haemost 1992; 67(04): 434-439
DOI: 10.1055/s-0038-1648466
Original Articles
Schattauer GmbH Stuttgart

The Effect of Suramin on Laboratory Tests of Coagulation

McDonald K Horne III
*   The Hematology Section, Clinical Pathology Department, Warren Grant Magnuson Clinical Center, and the Pharmacology Branch, Maryland, USA
,
Olga J Wilson
*   The Hematology Section, Clinical Pathology Department, Warren Grant Magnuson Clinical Center, and the Pharmacology Branch, Maryland, USA
,
Michael Cooper
**   The Hematology Section, Clinical Pathology Department, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
,
Harvey R Gralnick
*   The Hematology Section, Clinical Pathology Department, Warren Grant Magnuson Clinical Center, and the Pharmacology Branch, Maryland, USA
,
Charles E Myers
**   The Hematology Section, Clinical Pathology Department, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
› Author Affiliations
Further Information

Publication History

Received 04 July 1991

Accepted after revision 22 October 1991

Publication Date:
03 July 2018 (online)

Summary

The antitrypanosomal drug suramin, which has recently been under investigation as a cancer chemotherapeutic agent, has previously been found to induce heparin-like anticoagulants in treated patients. In the currently reported work suramin is shown to have an additional anticoagulant activity that is due to direct effects of the drug on procoagulant proteins. The studies were conducted with pooled normal plasma treated in vitro with suramin and with plasma samples obtained from patients who had received the drug intravenously for 2 weeks. It is demonstrated that in plasma suramin inhibits factors V, VIII, IX, X, XI, and XII, while thrombin, prothrombin, and factor VII are unaffected. The inhibition of factor V is virtually irreversible, although the effect of suramin on the other factors is readily reversed by dilution.

 
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