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Thromb Haemost 1992; 67(02): 189-192
DOI: 10.1055/s-0038-1648410
Original Articles
Schattauer GmbH Stuttgart

Type I Congenital Plasminogen Deficiency Is not a Risk Factor for Thrombosis

T Shigekiyo
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
,
Y Uno
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
,
A Tomonari
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
,
K Satoh
2   Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan
,
H Hondo
2   Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan
,
S Ueda
2   Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan
,
S Saito
1   The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan
› Author Affiliations
Further Information

Publication History

Received 09 April 1991

Accepted after revision 21 August 1991

Publication Date:
02 July 2018 (online)

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Summary

The risk of thrombosis in type I congenital plasminogen (PLG) deficiency has been suggested, but is still not confirmed. We studied 40 members of two unrelated families with this disease, and found that 21 were heterozygotes of type I congenital PLG deficiency. Three of them had thrombosis, but the other 18 had no thrombosis. The percentages of family members with no history of thrombosis up to a given age among subjects with type I congenital PLG deficiency and healthy controls were analyzed by the Kaplan-Meier method. No significant difference between the two groups was observed by the generalized Wilcoxon test (p = 0.23). These results suggest that there is no significant correlation between type I congenital PLG deficiency and thrombosis.

 

  • References

  • 1 Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 1965; 13: 516-530
    PubMedGoogle Scholar
  • 2 Girolami A, Marafioti F, Rubertelli M, Cappellato MG. Congenital heterozygous plasminogen deficiency associated with a severe thrombotic tendency. Acta Haematol 1986; 75: 54-57
    CrossrefPubMedGoogle Scholar
  • 3 Dolan G, Greaves M, Cooper P, Preston FE. Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds. Br J Haematol 1988; 70: 417-421
    CrossrefPubMedGoogle Scholar
  • 4 Hasegawa DK, Tyler BJ, Edson JR. Thrombotic disease in three families with inherited plasminogen deficiency. Blood Suppl (01) 1982; 60: 213a
    PubMedGoogle Scholar
  • 5 Lottenberg R, Dolly FR, Kitchens CS. Recurring thromboembolic disease and pulmonary hypertension associated with severe hypoplas-minogenemia. Am J Hematol 1985; 19: 181-193
    CrossrefPubMedGoogle Scholar
  • 6 Mannucci PM, Kluft C, Traas DW, Seveso P, D’Angelo A. Congenital plasminogen deficiency associated with venous thromboembolism: therapeutic trial with stanozolol. Br J Haematol 1986; 63: 753-759
    CrossrefPubMedGoogle Scholar
  • 7 Priollet P, Roncato M, Vayssairat M, Aiach M, Fiessinger JN, Mexme M, Leclerc M, Housset E. Von Recklinghausen neurofibromatosis and hereditary plasminogen deficiency. Dermatologica 1986; 172: 62-63
    CrossrefPubMedGoogle Scholar
  • 8 Tengborn L, Johannessen M, Hedner U. Family with hypoplas-minogenemia. Thromb Haemostas 1987; 58: 93 (Abstr)
    PubMedGoogle Scholar
  • 9 Mayer K, Hartmann H, Immel A, Seitz R, Egbring R. Congenital heterozygote hypoplasminogenemia as a risk factor for thrombosis. Fibrinolysis Suppl (02) 1988; 2: 37-38
    PubMedGoogle Scholar
  • 10 Hach-Wunderle V, Scharrer I, Lottenberg R. Congenital deficiency of plasminogen and its relationship to venous thrombosis. Thromb Haemostas 1988; 59: 277-280
    PubMedGoogle Scholar
  • 11 Tabernero MD, Gonzalez Sarmiento R, Tomas JF, Alberca I. Plasminogen deficiency in a Spanish family. Fibrinolysis Suppl (02) 1988; 2: 40-42
    PubMedGoogle Scholar
  • 12 Skoda U, Goldmann SF, Handler C, Hummel K, Lechler E, Lubcke I, Mauff G, Meyer-Bornecke D, Pesch S, Pulverer G. Plasminogen hemizygosity. Detection of a silent allele in 7 members of a family by determination of plasminogen phenotypes, antigenic levels, and functional activity. Vox Sang 1988; 54: 210-214
    CrossrefPubMedGoogle Scholar
  • 13 Robbins KC. The plasminogen-plasmin enzyme system. In: Hemostasis and Thrombosis. Basic Principles and Clinical Practice. Colman RW, Hirsh J, Marder VJ, Salzman ED. (eds). Lippincott; Philadelphia, PA: 1987. pp 340-357
    Google Scholar
  • 14 Suzuki K, Nishioka J. Plasma protein S activity measured using Protac, a snake venom derived activator of protein C. Thromb Res 1988; 49: 241-251
    CrossrefPubMedGoogle Scholar
  • 15 Laurell CB. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 1966; 15: 45-52
    CrossrefPubMedGoogle Scholar
  • 16 Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1966; 53: 457-481
    PubMedGoogle Scholar
  • 17 Gehan EA. A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrica 1965; 52: 203-223
    CrossrefPubMedGoogle Scholar
  • 18 Dolan G, Preston FE. Familial plasminogen deficiency and thromboembolism. Fibrinolysis Suppl (02) 1988; 2: 26-34
    PubMedGoogle Scholar
  • 19 Girolami A, Lazzaro A, Simioni P. Thrombotic manifestations in plasminogen deficiency and in plasminogen abnormalities. Thromb Haemostas 1988; 60: 528
    PubMedGoogle Scholar
  • 20 Miletich J, Sherman L, Broze Jr G. Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med 1987; 317: 991-996
    CrossrefPubMedGoogle Scholar
  • 21 Bertina RM, van der Linden IK, Engesser L, Muller HP, Brommer EJP. Hereditary heparin cofactor II deficiency and the risk of development of thrombosis. Thromb Haemostas 1987; 57: 196-200
    PubMedGoogle Scholar