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Thromb Haemost 1992; 67(01): 070-075
DOI: 10.1055/s-0038-1648383
Original Articles
Schattauer GmbH Stuttgart

On the Intraindividual and Gender Variability of Haemostatic Components

M Blombäck
1   The Depts. of Clinical Chemistry and Blood Coagulation, Stockholm, Sweden
,
P Eneroth
2   The Depts. of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden
3   The Unit for Applied Biochemistry, Clinical Research Centre, Huddinge Hospiial, Stockholm, Sweden
,
B-M Landgren
2   The Depts. of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden
,
M Lagerström
4   The Dept. of Psychology, University of Stockholm, Stockholm, Sweden
,
O Anderson
4   The Dept. of Psychology, University of Stockholm, Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received 27 December 1990

Accepted 21 August 1991

Publication Date:
02 July 2018 (online)

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Summary

The intraindividual variability in terms of coagulation analyses was explored in 10-16 samples collected from each of 15 women during one menstrual cycle. For comparison, six men were sampled six times during a period of 30 days. The following variables were analysed: FVII, FVIII, FX, vWF:Ag, vWF: ristocetin cofactor, fibrinogen, antithrombin, plasminogen and antiplasmin.

The results demonstrated mean coefficients of variation ranging between 4.5 (plasminogen) and 20.7 (vWF:Ag). In certain individuals, the intraindividual variability amounted to nearly 40%, in particular in the assays of FVIII and vWF: Ag. No direct relation between these two factors and oestradiol, progesterone or testosterone levels could be observed in our individuals.

The implications of these variations are discussed in terms of disease prediction and diagnosis of coagulation disorders.

 

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