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Thromb Haemost 1976; 36(02): 325-333
DOI: 10.1055/s-0038-1648048
Original Article
Schattauer GmbH

Effects of Fasting on Plasma and Platelet-Free Fatty Acids and Platelet Function in Healthy Males

Knut Gjesdal
1   Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway
,
Arne Nordøy
1   Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway
,
Harald Wang
1   Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway
,
Harald Berntsen
1   Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway
,
Ole D. Mjøs
1   Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway
› Author Affiliations
Further Information

Publication History

Received 27 October 1975

Accepted 30 April 1976

Publication Date:
03 July 2018 (online)

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Summary

10 healthy male volunteers fasted for 72 hours. Their plasma concentration of free fatty acid increased more than two-fold, to 1.8 mmol/1. The number of reversible venous “in vivo” platelet aggregates increased significantly (p <0.01); this figure correlated with the concentration of long-chain saturated free fatty acid in plasma (p <0.02). The correlation with the amount of long-chain saturated free fatty acid plus oleic acid (18:1) was even better (p <0.01). Plasma PF-4 concentration increased, suggesting increased platelet release reaction. In spite of the plasma increase, total platelet FFA concentration was reduced and there was a change in the distribution of platelet free fatty acid which correlated with the degree of aggregation.

 

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