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Thromb Haemost 1976; 35(03): 598-606
DOI: 10.1055/s-0038-1647958
Original Article
Schattauer GmbH

Alteration of Plasma Antithrombin III Levels in Ischemic Heart Disease

Robert H. Yue
1   Cardiovascular Research, Institute of Rehabilitation Medicine New York University Medical Center, New York, New York 10016, U.S.A.
,
Menard M. Gertler
1   Cardiovascular Research, Institute of Rehabilitation Medicine New York University Medical Center, New York, New York 10016, U.S.A.
,
Toby Starr
1   Cardiovascular Research, Institute of Rehabilitation Medicine New York University Medical Center, New York, New York 10016, U.S.A.
,
Russell Koutrouby
1   Cardiovascular Research, Institute of Rehabilitation Medicine New York University Medical Center, New York, New York 10016, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 05 June 1975

Accepted 10 October 1975

Publication Date:
02 July 2018 (online)

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Summary

The amount of anti thrombin III in plasma was determined quantitatively in 218 males between 45–60 years of age. The mean antithrombin III value was found to be low in the group with low risk for ischemic heart disease, intermediate in the group with high risk for ischemic heart disease and highest in the group with acute myocardial infarction. Concomitant study of kaolin-activated partial thromboplastin time revealed a sharp decrease in its mean value in the group with acute myocardial infarction. The high correlation between antithrombin III and kaolin-activated partial thromboplastin time for the entire population suggests that the development of ischemic heart disease is a gradual process and that failure of the damping mechanism results as an acute event. These findings may be useful in the determination of the coagulation state of these patients.

 

  • References

  • 1 Abildgaard U. 1969; Binding of Thrombin to Antithrombin III. Scandinavian Journal of Clinical and Laboratory Investigation 24: 23.
    CrossrefPubMedGoogle Scholar
  • 2 Alkjaersig N, Fletcher A. P, Sherry S. 1958; The Activation of Human Plasminogen II A Kinetic Study of Activation with Trypsin, Urokinase and Streptokinase. Journal of Biological Chemistry 233: 86.
    PubMedGoogle Scholar
  • 3 Biggs R, Denson K. W. E, Akman N, Borrett R, Had den M. 1970; Antithrombin III, Antifactor Xa and Heparin. British Journal of Haematology 19: 283.
    CrossrefPubMedGoogle Scholar
  • 4 Buluk K, Januszko T, Olbromski J. 1961; Conversion of Fibrin to Desmofibrin. Nature 191: 1093.
    PubMedGoogle Scholar
  • 5 Celander D. R, Guest M. M. 1955. Euglobulin Lysis Time. In: Tocantins L. M, Kazal L. A. (ed) Blood Coagulation, Hemmorrhage and Thrombosis . Grune and Stratton; New York: P 249.
    Google Scholar
  • 6 Coleman R. W. 1969; Activation of Plasminogen by Human Kallikrein. Biochemical and Biophysical Research Communication 35: 273.
    CrossrefPubMedGoogle Scholar
  • 7 Davie E. W, Ratnoff O. D. 1964; Waterfall Sequence for Intrinsic Blood Clotting. Science 145: 1310.
    CrossrefPubMedGoogle Scholar
  • 8 Dombrose F. A, Seegers W. H, Sedensky J. A. 1971; Antithrombin: Inhibition of Thrombin and Autoprothrombin (F-Xa) as a Mutual Depletion System. Thrombosis et Diathesis Haemorrhagica 26: 103.
    PubMedGoogle Scholar
  • 9 Gertler M. M, Woodbury M. A, Gottsch L. G, White P. D, Rusk H. A. 1959; The candidate for Coronary Heart Disease. Discriminating Power of Biochemical Hereditary and Anthropometric Measurements. Journal of American Medical Association 170: 149.
    PubMedGoogle Scholar
  • 10 Gertler M. M, Yue R. H, Leetma H. E, Leach C, Starr T. 1973. Alteration of Plasma Antithrombin III Level in Ischemic Heart Disease. Proceedings of IV Congress of the International Society of Thrombosis and Haemostasis, June 19-22 1973. Vienna; Austria:
    Google Scholar
  • 11 Glueck H, Sherry S, Troll W. 1954; Assay of Plasma Prothrombin with a Synthetic Substrate. Proceedings of the Society of Experimental Biology and Medicine 87: 646.
    PubMedGoogle Scholar
  • 12 Hedner U, Nilsson I. M. 1973; Antithrombin Illina Clinical Material. Thrombosis Research 3: 631.
    CrossrefPubMedGoogle Scholar
  • 13 Highsmith R. F, Rosenberg R. D. 1974; The Inhibition of Human Plasma by Human Antithrombin. Heparin Cofactor Journal of Biological Chemistry 249: 4335.
    PubMedGoogle Scholar
  • 14 Johnson A. J, Kline D. L, Alkjaersig N. 1969; Assay Methods and Standard Preparations for Plasmin, Plasminogen and Urokinase in Purified Systems, 1967–1968. Thrombosis et Diathesis Haemorrhagica 21: 259.
    PubMedGoogle Scholar
  • 15 Kaplan A. P, Schreiber A. D, Austen K. F. 1972; Isolation and Reaction Mechanisms of Human Plasma Plasminogen Activator and its Precursor. Federation Proceedings 31: 624 Abs.
    PubMedGoogle Scholar
  • 16 Lorand L, Konishi K. 1964; Activation of the Fibrin Stabilizing Factor of Plasma by Thrombin. Archives of Biochemistry and Biophysics 105: 58.
    CrossrefPubMedGoogle Scholar
  • 17 Lorand L, Konishi K, Jacobsen A. 1962; Transpeptidation Mechanism in Blood Clotting. Nature 194: 1148.
    CrossrefPubMedGoogle Scholar
  • 18 MacFarlane R. G. 1964; An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier. Nature 202: 498.
    CrossrefPubMedGoogle Scholar
  • 19 Marciniak E, Tsukamura S. 1972; Two Progressive Inhibitors of Factor X a in Human Blood. British Journal of Haematology 22: 341.
    CrossrefPubMedGoogle Scholar
  • 20 Niewlarowski S, Prou-Wartelle O. 1959; Role du facteur contact (facteur Hageman) dans la fibrinolyse. Thrombosis et Diathesis Haemorrhagica 3: 593.
    PubMedGoogle Scholar
  • 21 Pratt H. W. 1972. Alteration in Plasma Antithrombin III Activity in patients with Myocardial Infarction. Proceedings of the III Congress of the International Society of Thrombosis and Haemostasis, August 22-26 1972. Washington, D. C.:
    Google Scholar
  • 22 Proctor R. R, Rapaport S. I. 1961; The Partial Thromboplastin Time with Kaolin. American Journal of Clinical Pathology 36: 212.
    CrossrefPubMedGoogle Scholar
  • 23 Ratnoff O. D, Menzie C. 1951; A New Method for the Determination of Fibrinogen in Small Sample of Plasma. Journal of Laboratory and Clinical Medicine 37: 316.
    PubMedGoogle Scholar
  • 24 Rosenberg R. D, Damus P. S. 1973; The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor. Journal of Biological Chemistry 248: 6490.
    PubMedGoogle Scholar
  • 25 Seegers W. H. 1968; Antithrombin as a Proteinase Inhibitor. Annals of the New York Academy of Science 146: 593.
    CrossrefPubMedGoogle Scholar
  • 26 Seegers W. H, Cole E. R, Harmison C. R, Monkhouse F. C. 1964 Neutralization of Autoprothrombin C Activity with Antithrombin Canadian Journal of Biochemistry. 42. 359.
    PubMedGoogle Scholar
  • 27 Seegers W. H, Marciniak E. 1962; Inhibition of Autoprothrombin C Activity with Plasma. Nature 193: 1188.
    PubMedGoogle Scholar
  • 28 Soulier J. P, Prou-Wartelle O. 1959; Nouvelles dounees sur les facteurs Hageman et P. T. A., et sur le “contact”. Revue francaise d’estudes cliniques et biologiques 4: 932.
    PubMedGoogle Scholar
  • 29 Steinbuch M, Blatrix C, Josso F. 1967; α2-Macroglobulin as a Progressive Antithrombin. Nature 216: 500.
    CrossrefPubMedGoogle Scholar
  • 30 Yin E. T, Wessler S, Stoll P. J. 1976; Rabbit Plasma Inhibitor of the Activated Species of Blood Coagulation Factor X. Purification and Some Properties. Journal of Biological Chemistry 246: 3694.
    PubMedGoogle Scholar
  • 31 Yin E. T, Wessler S, Stoll P. J. 1971; b Biological Properties of the Naturally Occurring Plasma Inhibitor to Activated Factor X. Journal of Biological Chemistry 246: 3703.
    PubMedGoogle Scholar
  • 32 Yin E. T, Wessler S, Stoll P. J. 1971; c Identity of Plasma-Activated Factor X Inhibitor with Antithrombin III and Heparin Cofactor. Journal of Biological Chemistry 246: 3712.
    PubMedGoogle Scholar
  • 33 Yue R. H, Starr T, Gertler M. M. 1972. Antithrombin III Levels in Ischemic Thrombotic Vascular Diseases. Proceedings of the HI Congress of the International Society on Thrombosis and Haemostasis, August 22-26 1972. Washington, D. C.:
    Google Scholar
  • 34 Yue R. H, Starr T, Gertler M. M. 1973; Quantitative Determination of Total Antithrombin III in Plasma. Thrombosis et Diathesis Haemorrhagica 30: 84.
    PubMedGoogle Scholar
  • 35 Yue R. H, Starr T, Gertler M. M. 1974; The Rivanol Method for the Quantitative Determination of Antithrombin III in Plasma. Thrombosis et Diathesis Haemorrhagica 31: 123.
    PubMedGoogle Scholar