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Thromb Haemost 1994; 71(04): 526-527
DOI: 10.1055/s-0038-1642472
Letter to the Editor
Schattauer GmbH Stuttgart

β2-Glycoprotein I and Anticardiolipin Antibody Influence Factor Xa Generation but not Factor Xa Binding to Platelet-Derived Microparticles

Shosaku Nomura
1   First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Shirou Fukuhara
1   First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Yutaka Komiyama
2   Department of Clinico-Laboratory Medicine, Kansai Medical University, Osaka, Japan
,
Hakuo Takahashi
2   Department of Clinico-Laboratory Medicine, Kansai Medical University, Osaka, Japan
,
Eiji Matsuura
3   Immunology Laboratory, Yamasa Corporation, Choshi, Japan
,
Tomohiro Nakagaki
4   Chemo-Sero-Therapeutic Research Institute. Kumamoto, Japan
,
Akinobu Funatsu
4   Chemo-Sero-Therapeutic Research Institute. Kumamoto, Japan
,
Teruko Sugo
5   Institute of Hematology, Jichi Medical School, Tochigi, Japan
,
Michio Matsuda
5   Institute of Hematology, Jichi Medical School, Tochigi, Japan
,
Takao Koike
6   Second Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
› Author Affiliations
Further Information

Publication History

Received: 22 September 1993

Accepted after resubmission: 21 December 1993

Publication Date:
06 July 2018 (online)

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  • References

  • 1 Shi W, Chong BH, Hogg PJ, Chesterman CN. Anticardiolipin antibodies block the inhibition by B2 glycoprotein I of the factor Xa generating activity of platelets. Thromb Hacmostas 1993; 70: 342-345
    PubMedGoogle Scholar
  • 2 Schousboe I. β2-glycoprotein T: A plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood 1985; 66: 1086-1091
    PubMedGoogle Scholar
  • 3 Harris EN, Pierangeli S, Barquinero J, Ordi-Ros J. Anticardiolipin antibodies and binding of anionic phospholipids and serum protein. Lancet 1990; 336: 505-506
    CrossrefPubMedGoogle Scholar
  • 4 Koike T, Matsuura E. What is the “true” antigen for anticardiolipin antibodies?. Lancet 1991; 337: 671-672
    PubMedGoogle Scholar
  • 5 Shi W, Chong BH, Chesterman CN. β2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus a nticoagulants. Blood 1993; 81: 1255-1262
    PubMedGoogle Scholar
  • 6 Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem 1988; 263: 18205-18212
    PubMedGoogle Scholar
  • 7 Nomura S, Suzuki M, Kido H, Yamaguchi K, Fukuroi T, Yanabu M, Soga T, Nagata H, Kokawa T, Yasunaga K. Differences between platelet and microparticle glycoprotein Ilb/IIIa. Cytometry 1992; 13: 612-619
    PubMedGoogle Scholar
  • 8 Nomura S, Yanabu M, Fukuroi T, Kido H, Kawakatsu T, Yamaguchi K, Suzuki M, Kokawa T, Yasunaga K. Anti-phospholipid antibodies bind to platelet microparticles in idiopathic (autoimmune) thrombocytopenic purpura. Ann Hematol 1992; 65: 46-49
    CrossrefPubMedGoogle Scholar
  • 9 Nomura S, Komiyama Y, Murakami T, Funatsu A, Kokawa T, Sugo T, Matsuda M, Yasunaga K. Flow cytometric analysis of surface membrane proteins on activated platelets and platelet-derived microparticles from healthy and thrombasthenic individuals. Int J Hematol 1993; 58: 203-212
    PubMedGoogle Scholar
  • 10 Oosting JD, Derksen RHWM, Entjes HTI, Bouma BN, de Groot PG. Lupus anticoagulant activity is frequently dependent on the presence of β2-glycoprotein I. Thromb Haemostas 1992; 67: 499-502
    PubMedGoogle Scholar
  • 11 Galli M, Comfurius P, Barbui T, Zwaal RFA, Bevers EM. Anticoagulant activity of β2-glycoprotein I is potentiated by a distinct subgroup of anticardiolipin antibodies. Thromb Haemostas 1992; 68: 297-300
    PubMedGoogle Scholar
  • 12 Roubey RAS, Pratt CW, Buyon JP, Winfield JB. Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon β2-glycoprotein I. J Clin Invest 1992; 90: 1100-1104
    CrossrefPubMedGoogle Scholar
  • 13 McNeil HP, Chesterman CN, Krilis SA. Immunology and clinical importance of antiphospholipid antibodies. Adv Immunol 1991; 49: 193-280
    PubMedGoogle Scholar