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Vet Comp Orthop Traumatol 2006; 19(03): 133-141
DOI: 10.1055/s-0038-1632989
Review Article
Schattauer GmbH

Osteoinductive properties of the bone marrow Myth or reality

M. Tshamala
1   Departments of Medicine and Clinical Biology of Small Animals
2   Diagnostic Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
,
H. van Bree
2   Diagnostic Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
› Author Affiliations
Further Information

Publication History

Received 04 July 2005

Accepted 29 January 2006

Publication Date:
08 February 2018 (online)

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Summary

The osteogenic potential of red bone marrow was first reported more than 100 years ago. Since then, studies have reported controversial results that do not confirm nor disprove the capacity of fresh red bone marrow to produce bone. Researches have been focused on techniques that improve the efficiency of the bone marrow, including: the increase of the concentration of the mesenchymal stem cells in the aspirated bone marrow, the combination with a ‘carrier’ that helps to maintain the mesenchymal stem cells and guides and supports the vascular ingrowth in the defect, or the combination with bone growth factors that stimulate the marrow stromal cells to differentiate into bone forming cells. Each of these techniques has its drawbacks and increases the expenses of an operation. On the other hand, the synergistic effect observed with these combinations does not resolve the problem of the osteogenic capacity of pure bone marrow, which still remains questionable.

Keywords

Bone marrow - osteogenesis - osteoinduction - ceramics - growth factors
 

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