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Arthritis und Rheuma 2014; 34(02): 104-107
DOI: 10.1055/s-0037-1617982
Kinderrheumatologie: Übersichtsartikel
Schattauer GmbH

Autoinflammation und Autoimmunität

Autoinflammation and autoimmunity
K. Tenbrock
1   Klinik für Kinder und Jugendmedizin, Pädiatrische Rheumatologie, Uniklinik der RWTH Aachen, Aachen
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
27. Dezember 2017 (online)

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Zusammenfassung

Autoinflammation wird definiert als selbstgerichtete Entzündung, bei der lokale Faktoren zu einer Aktivierung von Zellen des angeborenen Immunsystems führen, mit der Folge einer Schädigung des lokalen Gewebes, die aber auch von einer generalisierten Entzündungsreaktion mit Fieber begleitet sein kann. Dahingegen wird Autoimmunität als selbst gerichtete Entzündung definiert, bei der pathologische Reaktionen von B- und T-Zellen zu einem Verlust von Toleranz gegenüber nativen Antigenen in den lymphatischen Geweben führen und zur Entwicklung einer Immunreaktion gegen diese Antigene. Die adaptive Immunantwort spielt hierbei die dominierende Rolle. Diese Zusammenfassung soll einen Überblick über beide Spielarten der Entzündung geben mit Fokus auf der Bedeutung des Inflammasoms und von IL-1β für den fließenden Übergang von Autoinflammation zur Autoimmunität.

Summary

Autoinflammation is described as self-directed inflammation, whereby local factors at sites predisposed to disease lead to activation of innate immune cells with resultant local target tissue damage but also generalized symptoms like fever. In contrast autoimmunity is recognized as self-directed inflammation, whereby pathologic B and T cell responses lymphoid organs lead to breaking of tolerance, with development of immune reactivity towards native antigens. The adaptive immune response plays the predominant role in the eventual clinical expression of disease. This review gives an overview over both parts of inflammation and focusses on the importance of the inflammasome and of IL-1ß for the blurred path from autoinflammation to autoimmunity.

Schlüsselwörter

Autoinflammation - Autoimmunität - B-Zellen - T-Zellen - Inflammasom - IL-1β

Keywords

Autoinflammation - autoimmunity - B cell - T cell - inflammasome - IL-1β
 

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