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Thromb Haemost 2001; 85(02): 221-225
DOI: 10.1055/s-0037-1615701
Review Article
Schattauer GmbH

Treatment with Simvastatin and Low-dose Aspirin Depresses Thrombin Generation in Patients with Coronary Heart Disease and Borderline-high Cholesterol Levels

Jacek Musiał
1   Dept. of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
,
Anetta Undas
1   Dept. of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
,
Robert Undas
1   Dept. of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
,
Jan Brożek
1   Dept. of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
,
Andrzej Szczeklik
1   Dept. of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
› Author Affiliations
Further Information

Publication History

Received 25 October 1999

Accepted after resubmission 19 September 2000

Publication Date:
08 December 2017 (online)

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Summary

Aspirin and statins are beneficial in coronary heart disease across a broad range of cholesterol levels. We assessed the effects of low-dose aspirin (75 mg daily) on thrombin generation in patients with coronary heart disease and average blood cholesterol levels. We also investigated whether in patients with borderline-high cholesterol level who have been already taking aspirin, additional treatment with simvastatin would affect thrombin generation.

Seven-day treatment with low-dose aspirin decreased thrombin generation ex vivo only in patients with total cholesterol 5.2 mmol/L. In patients with higher cholesterol levels aspirin had no effect. In these patients, already taking low-dose aspirin, additional three-month simvastatin treatment resulted in a reduction of thrombin generation. This demonstrates that low-dose aspirin depresses thrombin generation only in subjects with desirable blood cholesterol levels, while in others, with borderline-high cholesterol, thrombin formation is being reduced following the addition of simvastatin.

Keywords

Aspirin - simvastatin - thrombin generation
 

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