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Thromb Haemost 1998; 80(03): 370-371
DOI: 10.1055/s-0037-1615213
DOI: 10.1055/s-0037-1615213
Rapid Communications
Treatment with a GPIIb/IIIa Antagonist Inhibits Thrombin Generation in Platelet Rich Plasma from Patients
Further Information
Publication History
Received
17 March 1998
Accepted after revision
12 May 1998
Publication Date:
08 December 2017 (online)
Summary
Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fostering antithrombin activity, inhibits the formation of platelet-derived procoagulant microparticles, probably by decreasing the formation of free thrombin, which, under our circumstances, is the main platelet activator.
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