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DOI: 10.1055/s-0037-1614540
Inventory of Exogenous Hemostatic Factors Derived from Arthropods
On behalf of the Registry of Exogenous Hemostatic Factors of the Scientific and Standardization Subcommittee of the International Society on Thrombosis and Haemostasis; Registry Chairman: Neville MarshPublication History
Received
30 November 1998
Accepted
08 January 1999
Publication Date:
09 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199904/lookinside/thumbnails/10-1055-s-0037-1614540-1.jpg)
Summary
In many arthropods agents have been detected which affect the hemostatic mechanism. Some agents, such as those identified in hematophagus arthropods, seem to have evolved to help the animal in the feeding process while, in others, the function cannot be explained, but may be part of a defense mechanism (see Refs. 1-3).
Some arthropods possess several agents while in others one agent has different activities, i.e., antithrombin activity as well as inhibition of platelet aggregation. Many agents have been only partially characterized while others have been cloned and prepared in recombinant form.The majority of the agents are small proteins. As to the nomenclature, some agents have been described by the authors but have not been assigned proper names.
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References
- 1 Markwardt F. Coagulation inhibitors from blood sucking animals. A new line of developing antithrombotic drugs. Pharmazie. 1994; 49: 313-6.
- 2 Markwardt F. Coagulation inhibitors from animal feeding on blood. Rev Iberoamer Tromb Hemos. 1994; 7: 225-31.
- 3 Markwardt F. Antithrombotic agents from hematophagus animals. Clin Appl Thromb Hemostas 1996; 2: 75-82.
- 4 Parker KR, Mant MJ. Effects of tsetse (Glossina morsitans morsitans Westw). (Diptera: Glossinidae) salivary gland homogenate on coagulation and fibrinolysis. Thromb Haemost 1979; 42: 743-51.
- 5 Mant MJ, Parker KR. Two platelet aggregation inhibitors in tsetse (Glossina) saliva with studies of roles of thrombin and citrate in “in vitro” platelet aggregation. Brit J Haematol 1981; 48: 601-8.
- 6 Hawkins I R. Factors affecting blood clotting from salivary glands and crop of Glossina austeni. . Nature 1966; 212: 738-9.
- 7 Jacobs JW, Cupp EW, Sardana M, Friedman PA. Isolation and characterization of a coagulation Factor Xa inhibitor from black fly salivary glands. Thromb Haemost 1990; 64: 235-8.
- 8 Cupp MS, Cupp EW, Ramberg FB. Salivary gland apyrase in black flies (Simulium vittatum). . J Insect Physiol 1993; 39: 817-21.
- 9 Abebe M, Cupp MS, Ramberg FB, Cupp EW. Anticoagulant activity in salivary gland extracts of black flies (Diptera: Simuliidae). J Med Entomol 1994; 31: 908-11.
- 10 Abebe M, Cupp MS, Champagne D, Cupp EW. Simulidin: a black fly (Simulium vittatum) salivary gland protein with antithrombin activity. J Insect physiol 1995; 11: 1001-6.
- 11 Abebe M, Ribeiro JMC, Cupp MS, Cupp EW. Novel anticoagulant from salivary glands of Simulium vittatum (Diptera: Simuliidae) inhibits activity of coagulation factor V. J Med Entomol 1996; 33: 173-6.
- 12 Pinheiro FP, Bensabath G, Costa D, Maroja OM, Lins ZC, Andrade AHP. Haemorrhagic syndrome of Altamira. Lancet 1974; 1: 639-42.
- 13 Pinheiro FP. Síndrome Hermorrágica de Altamira. In Saúde Na Amazônia. Da Costa Linhares A, ed Instituiçoes Financeiras Itaú. Sao Paulo Brazil, 1983. pp. 107-8.
- 14 Bark N, Blombäck B, Fatah K. On the occurrence of thrombin-like enzymes in mosquitoes. Thromb Res 1996; 81: 623-34.
- 15 Stark KR, James AA. Salivary glands anticoagulants in culicine and anopheline mosquitoes (Diptera: Culicidae). J Med Entomol 1996; 33: 645-50.
- 16 Ribeiro JMC, Rossignol PA, Spielman A. Role of mosquito saliva in blood vessel location. J Exp Biol 1984; 108: 1-7.
- 17 Champagne DE, Smartt CT, Tibeiro JMC, James AA. The salivary glands-specific apyrase of the mosquito, Aedes aegypti, is a member of the 5’-nucleotidase family. Proc Nat Acad Sci USA 1995; 92: 694-8.
- 18 Cupp EW, Cupp MS, Ramberg FB. Salivary apyrase in African and New World vectors of Plasmodium species and its relationship to malaria transmission. Am J Trop Med Hyg 1994; 50: 235-40.
- 19 Ribeiro JMC, Rossignol PA, Spielman A. Salivary gland apyrase determines probing time in anopheline mosquitoes. J Insect Physiol 1985; 31: 689-92.
- 20 Mathews GV, Sidjanski S, Vanderberg JP. Inhibition of mosquito salivary gland apyrase activity by antibodies produced in mice immunized by bites of Anopheles stephensi mosquitoes. Am J Trop Med Hyg 1996; 55: 417-23.
- 21 Stark KR, James AA. A factor Xa-directed anticoagulant from the salivary glands of the yellow fever mosquito Aedes aegypti. . Exp Parasitol 1995; 81: 321-31.
- 22 Stark KR, James AA. Isolation and characterization of the gene encoding a novel factor Xa-directed anticoagulant from the yellow fever mosquito, Aedes aegypti. . J Biol Chem 1998; 273: 20802-9.
- 23 Cassiano O, Prigione B, Ricagni F, Riverso P. Considerazioni sum caso di morte per puntura di api. Minerva Anestesiologica 1981; 47: 761-4.
- 24 Tanphaichitr VS, Tuchinda M. Severe thrombocytopenic purpura following a bee sting. Ann Allergy 1982; 49: 229-31.
- 25 Cassiano O, Lombardi G, Ricagni F, D’Amico G, Parodi M. Comportamento del quadro emocoagulativo nell’avvelenamento da puntura di imenotteri. Minerva Anestesiologica 1983; 49: 411-6.
- 26 Ratnoff OD, Nossel HL. Wasp Sting Anaphylaxis. Blood 1983; 61: 132-9.
- 27 Van der Linden PWG, Hack CE, Struyvenberg A, Roem D, Brouwer MC, de Boer JP, van der Zwan JK. Controlled insect-sting challenge in 55 patients: correlation between activation of plasminogen and the development of anaphylactic shock. Blood 1993; 82: 1740-8.
- 28 Ouyang C, Huang TF. Effect of the purified phospholipases A2 from snake and bee venoms on rabbit platelet function. Toxicon 1984; 22: 705-18.
- 29 Kornberg A, Kaufman S, Silber L, Ishay JS. Effect of venom Sac extract of the oriental hornet (Vespa orientalis) on coagulation factors. Toxicon 1988; 26: 1169-76.
- 30 Hellmann K, Hawkins I R. Anticoagulant and fibrinolytic activities from Rhodnius prolixus Stå. Nature 1964; 201: 1008-9.
- 31 Hellmann K., Hawkins RI. Prolixin-S and Prolixin-G; Two anticoagulants from Rhodnius prolixus Stål. . Nature 1965; 207: 265-7.
- 32 Ribeiro JMC, Schneider M, Guimaraes JA. Purification and characterization of Prolixin-S (nitrophorin 2), the salivary anticoagulant of the bloodsucking bug Rhodnius prolixus . Biochem J 1995; 308: 243-9.
- 33 Zhang Y, Ribeiro JMC, Guimaraes J A, Walsh P P. Nitrophorin-2. A novel mixed-type reversible specific inhibitor of surface-dependent factor IXa catalyzed Factor-X activation. Abstract XVIth Cong Int Soc Thromb Haemost Thromb Haemost 1997; Suppl. 435-6.
- 34 Guimaraes JA, Schneider M, Ribeiro JM C. Disruption of fase complex by nitrophorin-2, the salivary anticoagulant of the blood-sucking bug R. prolixus. Abstract XVIth Cong Int Soc Throm Haemostas Thromb Haemost. Supl 1997. p 689.
- 35 Hawkins I R, Hellmann K. Investigations on a plasminogen activator in two blood-suckers, Rhodnius prolixus Stål and Hirudo medicinalis. Brit J Haemat 1966; 12: 86-91.
- 36 Markwardt F, Schulz E. Über einen Hemmstoff des Gerinnungsfermentes Thrombin aus blutsaugenden Raubwanzen ( Reduviiden) Naturwissenschaften. 1960; 47: 43.
- 37 Friedrich T, Kröger B, Bialojan S, Lemaire HG, Höffken HW, Reuschenbach P, Otte M, Dodt J. A Kazal-type inhibitor with thrombin specificity from Rhodnius prolixus. J Biol Chem 1993; 268: 16216-22.
- 38 van de Locht A, Lamba D, Bauer M, Huber R, Friedrich T, Kröger B, Höffken W, Bode W. Two heads are better than one: crystal structure of the insect derived double domain kazal inhibitor rhodniin in complex with thrombin. EMBO J 1995; 14: 5149-57.
- 39 Ribeiro JMC, Garcia ES. Platelet antiaggregating activity in the salivary secretion of the blood sucking bug Rhodnius prolixus. Experientia 1981; 37: 384-6.
- 40 Ribeiro JMC, Sarkis JF. Antithromboxane activity in Rhodnius prolixus salivary secretion. J Insect Physiol 1982; 28: 655-60.
- 41 Dodt J, Otte M, Strube KH, Friedrich T. Thrombin inhibitors of bloodsucking animals. Sem Thromb Haemost 1996; 22: 203-8.
- 42 Noeske-Jungblut C, Krätzschmar J., Haendler B, Becker A, Alagon A, Possani L, Donner P, Schleuning WD. Collagen-induced platelet aggregation is specifically inhibited by a salivary protein of the assassin Bug (Triatoma pallidipennis) Thromb Haemost. 1993; 69: 783.
- 43 Noeske-Jungblut C, Krätzschmar J, Haendler B, Alagon A, Possani L, Verhallen P, Donner P, Schleuning WD. An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis. . J Biol Chem 1994; 269: 5050-3.
- 44 Haendler B, Becker A, Noeske-Jungblut C, Krätzschmar J, Donner P, Schleuning WD. Expression of active recombinant pallidipin, a novel platelet aggregation inhibitor, in the periplasm of Escherichia coli. Biochem J 1995; 307: 465-70.
- 45 Haendler B, Becker A, Noeske-Jungblut C, Kratzschmar J, Donner P, Schleuning WD. Expresion, purification and characterization of recombinant pallidipin, a novel platelet aggregation inhibitor from the haematophageous triatomine bug Triatoma pallidipennis. . Blood Coag Fib 1996; 72: 183-6.
- 46 Noeske-Jungblut C, Haendler B, Donner P, Alagon A, Possani L, Schleuning WD. Triabin, a highly potent exosite inhibitor of thrombin. J Biol Chem 1995; 270: 28629-34.
- 47 Fuentes-Prior P, Noeske-Jungblut C, Schleuning WD, Huber R, Bade W. Structure of the thrombin complex with Triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomide bug. Proc Natl Aca Sci USA 1997; 11845-50.
- 48 Pereira MH, Souza ME, Vargas AP, Martins MS, Penido CM, Diotaiuti L. Anticoagulant activity of Triatoma infestans and Panstrongylus megistus saliva (Hemiptera/triatominae). Acta Trop 1996; 61: 255-61.
- 49 Ben Hamouda MH, Ammar M. Mise en évidence d’activateurs du plasminogène dans la salive d’un insecte prédateur de la famille des Reduviidae (Heteroptera). Archs Inst Pasteur Tunis 1984; 61: 73-95.
- 50 Ben Hamouda MH, Ammar M. Identification d’activateurs du plasminogène dans la salive de Rhapactor biparticeps (Reduviidae). Archs Inst Pasteur Tunis 1984; 61: 165-70.
- 51 Hellmann K, Hawkins I R. An antithrombin (Maculatin) and a plasminogen activator extractable from the blood-sucking hemipteran, Eutriatoma maculatus. . Brit J Haemat 1966; 12: 376-84.
- 52 Markwardt F, Lebereche E. Untersuchungen über den blutgerinnungshemmenden Wirkstoff der Tabaniden. Naturwissenschaften 1959; 46: 17-8.
- 53 Markwardt F, Schulz E. Über den Mechanismus der blutgerinnungshemmenden Wirkung des Tabanins. Naunyn-Schmiedebergs Arch Exp Path Pharmazie 1991; 46: 209-12.
- 54 Arocha-Piñango CL. Fibrinolisis producida por contacto con orugas. Acta Cient Ven 1969; 18: 136-91.
- 55 Arocha-Piñango CL, Layrisse M. Fibrinolysis produced by contact with caterpillars. Lancet 1969; 1: 810-2.
- 56 Marsh NA, Arocha-Piñango CL. Observation on a Saturnid moth caterpillar causing severe bleeding in man. Proc Royal Entomol Soc of London 1971; 36: 2-3.
- 57 Arocha-Piñango CL, Marsh NA, Robinson D. Fibrinolysis following contact with a saturnidae caterpillar. Problems related to fibrinolysis. J Clin Pathol 1972; 25: 614-56.
- 58 Arocha-Piñango CL, Perales JE, Gorzula S. Agentes fibrinoliticos en los líquidos biológicos de una oruga. Acta Cien Ven 1977; 28: 284-9.
- 59 Nouel de Brito A, Santos L, Caldera J, Sanchez V. Fibrinolisis producida por contacto con orugas. Estudio de un nuevo caso. X Jorn Soc Ven Hematol Abstract Book 1981; p 67.
- 60 Torres A, Duarte R, Pabon R, Arocha-Piñango CL, Rodriguez A, Argüello S, Gorzula S, Pabón S, Rodriguez S, Ojeda A, Carvajal Z. Sindrome hemorrágico producido por orugas. Presentación de nuevos casos. XI Jorn Ven Hemat Abstract Book 1983; p. 80.
- 61 Arocha-Piñango CL, Blumenfeld-Bosch N, Torres A, Perales J, Alonso M, Rodriguez S, Carvajal Z, Ojeda A, Tasayco M, Chitty W. Six new cases of caterpillar bleeding syndrome. Thromb Haemost 1992; 67: 402-7.
- 62 Fraiha-Neto H, Ballarini AJ, Llao RNQ, Costa Jr D, Dias LB. Sindrome hemorragico por contacto com larvas de Lonomia (Lepidoptera, saturnidae) In: Instituto Evandro Chagas. 50 años de contribuiçao as ciencias biologicas e a medicina tropical. Fundaçao Serviços de Saude Publica Belem Brazil 1986; 2: 811-20.
- 63 Fraiha-Neto H, Costa D, Quiroz de Leao RN, Ballarini AJ. Acidentes hemorrágicos por larvas de Lonomia. In: Plantas venenosas e animais peçohentos. S. Schvartsman, ed, Sarvier Pub Sao Paulo Brazil. 1992: 241-4.
- 64 Hommel D, Bouchareine L, Hulin A. Envenimation par une chenille de lépidoptera: Lonomia achelous. Revue de la litterature. A propos de deux cas en Guyane Française. Sem Hop Paris 1995; 71: 9-12.
- 65 Arocha-Piñango CL, Marsh NA, Robinson D. A proteolytic substance from a saturnidae moth caterpillar. Partial isolation and purification. Thromb Diat Haem 1973; 29: 135-42.
- 66 Arocha-Piñango CL, Pepper DS. Studies of a fibrinolytic enzyme from the larvae of Lonomia achelous (Cramer) using chromogenic peptide substrates. Thromb Haemost 1981; 46: 710-3.
- 67 Arocha-Piñango CL, Perales J, Carvajal Z. Studies on the degradation of fibrinogen by proteolytic enzymes from the larvae of Lonomia achelous (Cramer). Thromb Haemost 1981; 45: 233-6.
- 68 Arocha-Piñango CL. Enfermedad hemorrágica por orugas amazónicas. Una revisión. Interciencia 1987; 12: 16-20.
- 69 Arocha-Piñango CL, Blumenfeld-Bosh N, Nouel AL, Torres A, Perales J, Alonso ME, Rodriguez S, Carvajal Z, Ojeda A, Tasayco ML, Chitty W. Fibrinolytic and procoagulant agents from a saturnidae moth caterpillar. In Hemostasis and animal venoms. Pirkle H, and Markland FS. eds Marcel Dekker Inc; Pub New York: 1988. pp 223-40.
- 70 Amarant T, Burkhart W, Levine H, Arocha-Piñango CL, Parikh I. Isolation and complete amino acid sequence of two fibrinolytic proteinases from the toxic saturnid caterpillar Lonomia achelous. . Biochem Biophys Acta 1991; 1079: 214-21.
- 71 Guerrero B, Arocha-Piñango CL. Activation of human factor II, V and XIII by the haemolymph of Lonomia achelous caterpillars. Thromb Haemost 1989; 62: 77.
- 72 Guerrero B, Arocha-Piñango CL. Activation of human prothrombin by the venom of Lonomia achelous (Cramer) caterpillars. Thromb Res 1992; 66: 169-78.
- 73 Guerrero B, Arocha-Piñango CL, Gil San Juan A. Lonomia achelous caterpillar venom (LACV) selectively inactivate blood clotting Factor XIII. Thromb Res 1997; 87: 83-93.
- 74 Guerrero B, Arocha-Piñango CL, Gil San, Juan A. Degradation of human Factor XIII by Lonomin V, a purified fraction of Lonomia achelous caterpillar venom. Thromb Res 1997; 87: 171-81.
- 75 Kellen EMA, Picarelli ZP, Duarte AC. Hemorrhagic syndrome induced by contact with caterpillars of the genus Lonomia. (Saturnidae, hemileucinae) J Toxicol Rev 1995; 14: 283-308.
- 76 Kellen EMA, Duarte AC, Tomy SC, Sano-Martins IS, Morena P, Castro SC, Guerrero B, Arocha-Piñango CL. Sindrome hemorrágica induzida por contacto com lagartas de lepidopteros Lonomia obliqua (Saturniidae) no sul do brasil XXXI Congreso da Sociedad Brasileira de Medicina Tropical. Abstract Book 1995; p 169.
- 77 Duarte CA, Caovilla J, Lorini I, Lorini D, Mantorani G, Sumida J, Manfre PC, Silveira R, Moura SP. Insuficiencia renal aguda por acidentes com lagartas. J Bras Nefrol 1990; 12: 184-7.
- 78 Duarte A, Lorini I, Schilling MA. Acidentes hemorrágicos por contato com taturanas no Rio Grande do Sul. Mem Inst Butantan 1990; 52 (Suppl. 02) (supp) 82-5.
- 79 Chudzinski Tavassi AM, Reis CV, Gonçalves LRC, Kelen EMA. Isolation of a procoagulant protein from bristles of Lonomia obliqua caterpillars. 12th World Congress on animal, plant and microbial toxins. Cuernavaca; Mexico: 1997. (Abstract).
- 80 Donato JL, Moreno RA, Hyslop S, Duarte A, Antunes E, Le Bonniec BF, Rendu F, de Nucci G. Lonomia obliqua caterpillars spicules trigger human blood coagulation via activation of Factor X and prothrombin. Thromb Haemost 1998; 78: 539-42.
- 81 Rocha-Campos ACM, Alves EW, Melo PD, Machado OLT, Dias da Silva W. Lonomiatoxin: a 20 kDa protein present in bristles extracts of Lonomia obliqua caterpillars extracts. 12th World Congress on animal, plant and microbial toxins. Cuernavaca; Mexico: 1997. (Abstract).
- 82 Devi CS, Reddy CN, Devi SL, Subrahmanyam YR, Bhatt HV, Suvarnakumari G, Murthy DP, Reddy CRRM. Defibrination syndrome due to scorpion venom poisoning. Brit Med J 1970; 1: 345-7.
- 83 Reddy CRRM, Suvarnakumari G, Devi CS, Reddy CN. Pathology of scorpion venom poisoning. J Tro Med Hyg 1972; 75: 98-100.
- 84 Gajalakshmi BS. Coagulation studies following scorpion venom injection in animals. Indian J Med Res 1982; 76: 337-41.
- 85 Hamilton PJ, Ogston D, Douglas AS. Coagulant activity of the scorpion venoms Palamneus gravimanus and Leiurus quinquestriatus . Toxicon 1974; 12: 291-6.
- 86 Taylor E, Denny W. Hemolysis, renal failure and death, presumed secondary to bite of brown recluse spider. Southern Med J Ass 1966; 59: 1209-11.
- 87 Wasserman GS, Anderson PC. Loxoscelism and necrotic arachnidism. J Toxicol-Clin Toxicol 1983; 21: 451-72.
- 88 Berger RS, Adelstein EH, Anderson PC. Intravascular coagulation: The cause of necrotic arachnidism. J Invest Dermatol 1973; 61: 142-50.
- 89 Rees RS, O’Leary JP, King LE. The pathogenesis of systemic loxoscelism following brown recluse spider bites. J Surgical Res 1983; 35: 1-10.
- 90 Rees R, Hawiger J, Des Prez RM, King LE. Mechanisms of platelet injury associated with dermonecrosis resulting from brown recluse spider venom. Clin Res 1982; 30: 265A.
- 91 Rees RS, Gates C, Timmons S, Des Prez RM, King LE. Plasma components are required for platelet activation by the toxin of Loxosceles reclusa . Toxicon 1988; 26: 1035-45.
- 92 Babcock JL, Marmer DJ, Steele RW. Immunotoxicology of brown recluse spider (Loxosceles reclusa) venom. Toxicon 1986; 24: 783-90.
- 93 McGlasson DL, Babcock JL, Berg L, Triplett DA. ARACHnase. An evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents. Am J Clin Pathol 1993; 100: 576-8.
- 94 McGlasson DL, Babock JL, Patterson WR. Evaluation of the lupus anticoagulant effects of brown recluse spider venom or normal plasma. J Mil Med Lab Sci 1989; 18: 95-8.
- 95 Bascur L, Yevenes I, Barja P. Effects of Loxosceles laeta spider venom on blood coagulation. Toxicon 1982; 20: 795-6.
- 96 Usmanov PB, Nuritova FA. The anticoagulant action of phospholipase A from Eresus niger spider venom. Toxicon. 1994; 32: 625-8.
- 97 Sohn YD, You WK, Kim KY, Chung KH, Moon HM, Park DH. Cloning of a cDNA for a novel plasminogen activator from a Korean centipede. Fibrinolysis 1996; 10: 7-A22.
- 98 Hawkins I R, Hellmann K. Factors affecting blood clotting from the tick Ornithodoros moubata. . J Physiol 1966; 85: 70.
- 99 Hellmann K, Hawkins I R. The action of tick extracts on blood coagulation and fibrinolysis. Thromb Diat Haem 1967; 18: 617-25.
- 100 van de Locht A, Stubbs MM, Bode W, Friedrich T, Bollschweiler C, Höffken W, Huber R. The ornithodorin-thrombin crystal structure, a key to the TAP enigma?. EMBO J 1996; 15: 6011-7.
- 101 Waxman L, Smith DE, Arcuri KE, Vlasuk GP. Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation Factor Xa. Science 1990; 248: 593-6.
- 102 Dunwiddie CT, Waxman L, Vlasuk GP, Friedman PA. Purification and characterization of inhibitors of blood coagulation Factor Xa from hematophagous organisms. In Methods in Enzymology. Academic Press 1991; 223: 291-312.
- 103 Neeper MP, Waxman L, Smith DE, Schulman CA, Sardana M, Ellis RW, Schaffer LW, Siegl PK, Vlasuk GP. Characterization of recombinant Tick Anticoagulant Peptide. A highly selective inhibitor of blood coagulation factor Xa. J Biol Chem 1990; 265: 17746-52.
- 104 Jordan SP, Waxman L, Smith DE, Vlasuk GP. Tick Anticoagulant Peptide: Kinetic analysis of the recombinant inhibitor with blood coagulation factor Xa. Biochemistry 1990; 29: 11095-100.
- 105 Vlasuk GP. Structural and functional characterization of tick anticoagulant peptide (TAP) a potent and selective inhibitor of blood coagulation factor Xa. Thromb Haemost 1993; 70: 212-6.
- 106 Sardana M, Sardana V, Rodkey J, Wood T, Ng A, Vlasuk GP, Waxman L. Determination of disulfide bond pairs and stability in recombinant tick anticoagulant peptide. J Biol Chem 1991; 266: 13560-3.
- 107 Antuch W, Guntert P, Billeter M, Hawthorne T, Grossenbacher H, Wutreich K. NMR solution structure of the recombinant tick anticoagulant protein (rTAP): a Factor Xa inhibitor from the tick Ornithodorus moubata. . FEBS-Lett 1994; 352: 251-7.
- 108 Dunwiddie CT, Neeper MP, Nutt EM, Waxman L, Smith DE, Hofmann KJ, Lumma PK, Garsky VM, Vlasuk GP. Site-directed analysis of the functional domains in the Factor Xa inhibitor Tick Anticoagulant Peptide: identification of two distinct regions that constitute the enzyme recognition sites. Biochemistry 1992; 31: 12126-31.
- 109 Krishnaswamy S, Vlasuk G, Bergum PW. Assembly of the prothrombinase complex enhances the inhibition of bovine factor Xa by Tick Anticoagulant Peptide. Biochemistry 1994; 33: 7897-907.
- 110 Karczewski J, Waxman L, Endris RG, Connolly TM. An inhibitor from the argasid tick Ornithodoros moubata of cell adhesion to collagen. Biochem Biophys Res Commun 1995; 208: 532-41.
- 111 Karczewski J, Endris R, Connolly TM. Disagregin is a fibrinogen receptor antagonist lacking the Arg-Gly-Asp sequence from the tick, Ornithodoros moubata. . J Biol Chem 1994; 269: 6702-8.
- 112 Waxman L, Connolly TM. Isolation of an inhibitor selective for collagen-stimulated platelet aggregation from the soft tick Ornithodoros moubata. . J Biol Chem 1993; 268: 5445-9.
- 113 Keller PM, Waxman L, Arnold BA, Schultz LD, Condra C, Connolly TM. Cloning of the cDNA and expression of moubatin, an inhibitor of platelet aggregation. J Biol Chem 1993; 268: 5450-6.
- 114 Gaspar AR, Crause JC, Neitz AW. Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi. . Exp Appl Acarol 1995; 19: 117-27.
- 115 Limo MK, Voigt WP, Tumbo-Oeri AG, Njogu RM, Ole-MoiYoi OK. Purification and characterization of an anticoagulant from the salivary glands of the Ixodid Tick Rhipicephalus appendiculatus. . Experimental Parasitology 1991; 72: 418-29.
- 116 Nuttall HF, Strickland C. On the presence of an anticoagulant in the salivary glands and intestines of Argas persicus. . Parasitology 1908; 1: 302-10.
- 117 Sabbatini L. Fermento anticoagulante dell’ Ixodes ricinus. . Arch Ital Biol 1989; 31: 37.
- 118 Markwardt F, Landmann H. Untersuchungen über den blutgerinnungshemmenden Wirkstoff der Zecke Ixodes ricinus. . Naturwissenschaften 1958; 45: 398-9.
- 119 Hoffman A, Walsmann P, Ricsehner G, Paintz M, Markwardt F. Isolation and characterization of a thrombin inhibitor from the ticks Ixodes ricinus Pharmazie. 1991; 46: 209-12.
- 120 Ribeiro JMC, Makoul GT, Levine J, Robinson DR, Spielman A. Anti-hemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini . J Exp Med 1985; 161: 332-44.
- 121 Anastopoulus P, Thurn MJ, Broady KW. Anticoagulant in the tick Ixodes holocyclus. . Aust Vet J 1991; 68: 366-7.
- 122 Gordon JR, Allen JR. Factors V and VII anticoagulant activities in the salivary glands of feeding Dermacentor andersoni ticks. J Parasitol 1991; 77: 167-70.
- 123 Wang X, Coons LB, Taylor DB, Stevens SE, Gartner TK. Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. . J Biol Chem 1996; 271: 17785-90.
- 124 Tatchell RJ, Binnington KC. An active constituent of the saliva of the cattle tick, Boophilus microplus. Proc 3rd. Int Congress of Acarology Prague 1971; 745-8.
- 125 Willadsen P, Riding GA. On the biological role of a proteolytic-enzyme inhibitor from the ectoparasitic tick Boophilus microplus. . Biochem J 1980; 189: 295-303.
- 126 Maruo K, Akaike T, Matsumura Y, Kohmoto S, Inada Y, Ono T, Arao T, Maeda H. Triggering of the vascular permeability reaction by activation of the Hageman Factor-prekallikrein system by house dust mite proteinase. Biochem Biophys Acta 1991; 1074: 62-8.
- 127 Matsushima A, Shioya K, Kobayashi M, Kodera Y, Inada Y. Activation of fibrinolysis with the protease from Dermatophagoides farinae. . Thromb Haemost 1993; 70: 545.
- 128 Matsushima A, Shioya K, Kobayashi M, Kodera Y, Inada Y. Activation of blood coagulation system with the protease from Dermatophagoides farinae. . Thromb Haemost 1993; 69: 531-532.