Thromb Haemost 2004; 92(06): 1446-1447
DOI: 10.1055/s-0037-1614302
Case Report
Schattauer GmbH

Impaired platelet responses to clopidogrel and ticlopidine in a patient with recurrent coronary stent stenosis

Achim Obergfell
1   Institut für Klinische Biochemie und Pathobiochemie & Zentrallabor, Universitätsklinikum, Würzburg, Germany
,
Jörg Strotmann
2   Medizinische Klinik, Universitätsklinikum, Würzburg, Germany
,
Andreas Bonz
2   Medizinische Klinik, Universitätsklinikum, Würzburg, Germany
,
Johann Bauersachs
2   Medizinische Klinik, Universitätsklinikum, Würzburg, Germany
,
Georg Ertl
2   Medizinische Klinik, Universitätsklinikum, Würzburg, Germany
,
Ulrich Walter
1   Institut für Klinische Biochemie und Pathobiochemie & Zentrallabor, Universitätsklinikum, Würzburg, Germany
,
Ralf Grossmann
1   Institut für Klinische Biochemie und Pathobiochemie & Zentrallabor, Universitätsklinikum, Würzburg, Germany
› Author Affiliations
Further Information

Publication History

Received 12 August 2004

Accepted after revision 26 September 2004

Publication Date:
14 December 2017 (online)

 

 
  • References

  • 1 Barragan P, Teuma X, Botosezzy I. et al. Resistance to Thienopyridine: Clinical detection of coronary stent thrombosis by monitoring of vasodilator stimulated phosphoprotein phosphorylation. Cathet Cardiovasc Intervent 2003; 59: 295-302.
  • 2 Schwarz UR, Geiger J, Walter U. et al. Flow cytometric analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets. Thromb Haemost 1999; 82: 1145-52.
  • 3 Herbert JM, Savi P. P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med 2003; 03: 113-22.
  • 4 Geiger J, Brich J, Honig-Liedl P. et al. Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel. Arterioscler Thromb Vasc Biol 1999; 19: 2007-11.
  • 5 Hollopeter G, Jantzen HM, Vincent D. et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001; 409: 202-7.
  • 6 Foster CJ, Prosser DM, Agans JM. et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001; 107: 1591-98.
  • 7 Savi P, Pereillo JM, Uzabiaga MF. et al. Identification and biological activity of the active metabolite of clopidogrel. Thromb Haemost 2000; 84: 891-96.
  • 8 Bertrand ME, Rupprecht HJ, Urban P. et al. for the CLASSICS investigators. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting. Circulation 2000; 102: 624-9.
  • 9 Järemo P, Lindahl TL, Fransson SG. et al. Individual variations of platelet inhibition after loading doses of clopidogrel. J Int Med 2002; 252: 233-8.
  • 10 Grossmann R, Sokolova O, Schnurr A. et al. Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thromb Haemost 2004; 92: 1201-6.
  • 11 Matetzky S, Shenkman B, Guetta V. et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004; 109: 3171-5.
  • 12 Kastrati A, Von Beckerath N, Joost A. et al. Loading With 600 mg Clopidogrel in Patients With Coronary Artery Disease With and Without Chronic Clopidogrel Therapy. Circulation. 2004 July 19 Epub.
  • 13 Hermann A, Rauch BH, Braun M. et al. Platelet CD40 ligand (CD40L) – subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets 2001; 12: 74-82.
  • 14 Wiviott SD, Antman EM. Clopidogrel resistance: a new chapter in a fast-moving story. Circulation 2004; 109: 3064-7.
  • 15 Hermann A, Weber AA, Schror K. Clopidogrel inhibits platelet adhesion and platelet-dependent mitogenesis in vascular smooth muscle cells. Thromb Res 2002; 105: 173-5.
  • 16 Cheneau E, Leborgne L, Mintz GS. et al. Predictors of subacute stent thrombosis: results of a systematic intravascular ultrasound study. Circulation 2003; 108: 43-7.