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J Pediatr Infect Dis 2008; 03(04): 229-233
DOI: 10.1055/s-0035-1556994
Original Article
Georg Thieme Verlag KG Stuttgart – New York

Outcome of infections with extended spectrum beta-lactamase producing organisms in children

Ravi Jhaveri
a   Department of Pediatrics, Division of Infectious Diseases, Duke Children's Hospital, Durham, NC, USA
,
David Bronstein
b   Department of Pediatrics, Division of Infectious Diseases, Kaiser Permanente Medical Center, Lancaster, CA, USA
,
Janet Sollod
c   Department of Pediatrics, Division of Infectious Diseases, California Pacific Medical Center, San Francisco, CA, USA
,
Christina Kitchen
d   Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
,
Paul Krogstad
e   Department of Pediatrics, Division of Infectious Diseases, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA
› Author Affiliations
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Further Information

Publication History

17 March 2008

30 July 2008

Publication Date:
28 July 2015 (online)

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Abstract

Infections with organisms producing extended-spectrum beta-lactamases are associated with well established risk factors and poor outcomes in adults, but these are less well defined in children. Our case-control analysis showed that infections with extended-spectrum beta-lactamases producing organisms are linked to prolonged antibiotic usage and are possibly associated with prolonged length of stay and worse overall outcomes in hospitalized children. Efforts to limit the duration and narrow the spectrum of antimicrobial therapy may assist in controlling infections due to these organisms.

Keywords

ESBL - extended-spectrum beta-lactamases - antimicrobials - E. coli - K. pneumoniae - children - pediatrics