Zirkadiane Uhren und Energiestoffwechsel: Implikationen für die Gesundheit

Abstract

On behavioural as well as physiological levels our daily life is regulated by the circadian clock – endogenous oscillators present in the hypothalamus and in peripheral tissues – which is believed to have evolved as an adaptation to Earth rotation around the Sun and its consequent 24 h dark-light cycle. Accumulative evidence suggests that the circadian clock plays a pivotal role for energy metabolism and energy homeostasis: many hormones, enzymes and transport systems involved in the regulation of energy metabolism have been shown to display circadian rhythms in their expression, secretion and/or activity patterns. The energy metabolism, in turn, can impact on the circadian clock – a process that is called entrainment. Thus, the circadian clock and energy metabolism are intimately intertwined. So far this interplay and its implications for health have not been understood very well. For health maintenance, however, it seems to be crucial to avoid any desynchronisation between the circadian clock and energy metabolism. Form a clinical point of view this might be important for the treatment of obesity and associated disorders and may lead to new life-style approaches.

Schlüsselwörter

zirkadiane Uhr - Energiestoffwechsel - Phasenverschiebung - Clock-Gene - zirkadiane Desynchronisation - metabolische Erkrankungen

Keywords

circadian clock - energy metabolism - entrainment - clock genes - circadian desynchronisation - metabolic diseases

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