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Klin Monbl Augenheilkd 2014; 231(4): 368-373
DOI: 10.1055/s-0034-1368213
Klinische Studie
Georg Thieme Verlag KG Stuttgart · New York

Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

Posterior Pole Asymmetrie Analyse mittels OCT
L. Kochendörfer
1   UniversityHospital Zurich, Department of Ophthalmology, Zurich, Switzerland
,
P. Bauer
2   Cantonal Hospital Winterthur, Department of Ophthalmology, Winterthur, Switzerland
,
J. Funk
1   UniversityHospital Zurich, Department of Ophthalmology, Zurich, Switzerland
,
M. Töteberg-Harms
1   UniversityHospital Zurich, Department of Ophthalmology, Zurich, Switzerland
3   Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, U. S. A.
› Author Affiliations
Further Information

Publication History

received 27 August 2013

accepted 01 January 2014

Publication Date:
25 April 2014 (online)

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Abstract

Background: The aim of this study was to evaluate the reproducibility of the posterior pole asymmetry analysis (PPAA) in glaucomatous eyes and healthy controls in comparison to retinal nerve fiber layer measurements (RNFL) with spectral domain optical coherence tomography (SD-OCT).

Patients and Methods: Prospectively, in a single session by one operator, three measurements were taken of the retinal thickness with the PPAA and three measurements of the RNFL with the eye-tracker function of the Heidelberg Spectralis SD-OCT.

Results: The mean intraclass correlation coefficient (ICC) and lower confidence intervals (in parentheses) for PPAA were 0.98 (0.96) in both healthy (36 eyes) and glaucomatous eyes (26 eyes). Global coefficients of variation (COVs) were between 0.0 and 1.1 % in healthy controls and between 0.0 and 1.9 % in glaucoma eyes. Global ICCs for RNFL were 0.98 (0.96) in healthy controls and 0.98 (0.97) in glaucoma eyes and global COVs were between 0.0 and 6.8 % in healthy controls and between 0.0 and 3.0 % in glaucoma eyes.

Conclusion: Reproducibility of the PPAA was good and exceeds that of established RNFL measurements. Thus, PPAA is an additional useful tool in management of glaucoma.

Zusammenfassung

Hintergrund: Ziel war, die Reproduzierbarkeit der Posterior-Pole-Asymmetrie-Analyse (PPAA) in glaukomatösen und gesunden Augen im Vergleich zur peripapillären Nervenfaserschichtdickenmessung (RNFL) mit dem OCT zu evaluieren.

Patienten und Methoden: Prospektiv erfolgten in einer Sitzung von einem Untersucher 3 Messungen der Netzhautdicke von der PPAA und 3 Messungen von der RNFL unter Verwendung der Eye-Tracker-Funktion mit dem Heidelberg Spectralis SD-OCT.

Ergebnisse: Die Intraklassenkorrelation (ICC) betrug für die PPAA sowohl bei den gesunden (36 Augen) als auch bei den glaukomatösen Augen (26 Augen) 0,98 (0,96 Konfidenzintervall). Der Variationskoeffizient (COV) war bei gesunden Augen zwischen 0,0 und 1,1 %, bei glaukomatösen Augen zwischen 0,0 und 1,9 %. Die ICC für die RNFL betrug 0,98 (0,96) in gesunden Augen und 0,98 (0,97) in glaukomatösen Augen, der COV bewegte sich zwischen 0,0 und 6,8 % in gesunden und zwischen 0,0 und 3,0 % in glaukomatösen Augen.

Schlussfolgerungen: Die Reproduzierbarkeit mit der PPAA ist außerordentlich hoch und übertrifft sogar die der etablierten RNFL-Messung. Die PPAA ist ein zusätzliches, hilfreiches Instrument im Glaukommanagement.

Key words

optical coherence tomography - spectral-domain optical coherence tomography - SD-OCT - spectralis OCT - OCT - reproducibility - glaucoma - posterior pole asymmetry analysis

Schlüsselwörter

optische Kohärenztomografie - Spectral-Domain optische Kohärenztomografie - SD-OCT - Spectralis-OCT - OCT - Reproduzierbarkeit - Glaukom - Posterior-Pole-Asymmetrie-Analyse
 

  • References

  • 1 Sommer A, Katz J, Quigley HA et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 1991; 109: 77-83
    Google Scholar
  • 2 Wollstein G, Schuman JS, Price LL et al. Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields. Am J Ophthalmol 2004; 138: 218-225
    CrossrefPubMedGoogle Scholar
  • 3 Ajtony C, Balla Z, Somoskeoy S et al. Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by optical coherence tomography. Invest Ophthalmol Vis Sci 2007; 48: 258-263
    CrossrefPubMedGoogle Scholar
  • 4 Horn FK, Mardin CY, Laemmer R et al. Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT. Invest Ophthalmol Vis Sci 2009; 50: 1971-1977
    CrossrefPubMedGoogle Scholar
  • 5 Toteberg-Harms M, Sturm V, Knecht PB et al. Repeatability of nerve fiber layer thickness measurements in patients with glaucoma and without glaucoma using spectral-domain and time-domain OCT. Graefes Arch Clin Exp Ophthalmol 2012; 250: 279-287
    CrossrefPubMedGoogle Scholar
  • 6 Langenegger SJ, Funk J, Toteberg-Harms M. Reproducibility of retinal nerve fiber layer thickness measurements using the eye tracker and the retest function of Spectralis SD-OCT in glaucomatous and healthy control eyes. Invest Ophthalmol Vis Sci 2011; 52: 3338-3344
    CrossrefPubMedGoogle Scholar
  • 7 Asrani S, Rosdahl JA, Allingham RR. Novel software strategy for glaucoma diagnosis: asymmetry analysis of retinal thickness. Arch Ophthalmol 2011; 129: 1205-1211
    CrossrefPubMedGoogle Scholar
  • 8 Ghasia FF, El-Dairi M, Freedman SF et al. Reproducibility of Spectral-Domain Optical Coherence Tomography Measurements in Adult and Pediatric Glaucoma. J Glaucoma 2013; DOI: 10.1097/IJG.0b013e31829521db.
    PubMedGoogle Scholar
  • 9 Lee SH, Kim SH, Kim TW et al. Reproducibility of retinal nerve fiber thickness measurements using the test-retest function of spectral OCT/SLO in normal and glaucomatous eyes. J Glaucoma 2010; 19: 637-642
    CrossrefPubMedGoogle Scholar
  • 10 Bagga H, Greenfield DS, Knighton RW. Macular symmetry testing for glaucoma detection. J Glaucoma 2005; 14: 358-363
    CrossrefPubMedGoogle Scholar
  • 11 Lee SH, Kim SH, Kim TW et al. Reproducibility of retinal nerve fiber thickness measurements using the test-retest function of spectral OCT/SLO in normal and glaucomatous eyes. J Glaucoma 2010; 19: 637-642
    CrossrefPubMedGoogle Scholar
  • 12 Mwanza JC, Chang RT, Budenz DL et al. Reproducibility of peripapillary retinal nerve fiber layer thickness and optic nerve head parameters measured with cirrus HD-OCT in glaucomatous eyes. Invest Ophthalmol Vis Sci 2010; 51: 5724-5730
    CrossrefPubMedGoogle Scholar
  • 13 Menke MN, Knecht P, Sturm V et al. Reproducibility of nerve fiber layer thickness measurements using 3D fourier-domain OCT. Invest Ophthalmol Vis Sci 2008; 49: 5386-5391
    CrossrefPubMedGoogle Scholar
  • 14 Garas A, Vargha P, Hollo G. Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph. Ophthalmology 2010; 117: 738-746
    CrossrefPubMedGoogle Scholar
  • 15 Serbecic N, Beutelspacher SC, Aboul-Enein FC et al. Reproducibility of high-resolution optical coherence tomography measurements of the nerve fibre layer with the new Heidelberg Spectralis optical coherence tomography. Br J Ophthalmol 2011; 95: 804-810
    CrossrefPubMedGoogle Scholar
  • 16 Wu H, de Boer JF, Chen TC. Reproducibility of retinal nerve fiber layer thickness measurements using spectral domain optical coherence tomography. J Glaucoma 2011; 20: 470-476
    PubMedGoogle Scholar
  • 17 Menke MN, Dabov S, Knecht P et al. Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography. Am J Ophthalmol 2009; 147: 467-472
    CrossrefPubMedGoogle Scholar
  • 18 Pierro L, Giatsidis SM, Mantovani E et al. Macular thickness interoperator and intraoperator reproducibility in healthy eyes using 7 optical coherence tomography instruments. Am J Ophthalmol 2010; 150: 199-204.e1
    CrossrefPubMedGoogle Scholar
  • 19 Wolf-Schnurrbusch UE, Ceklic L, Brinkmann CK et al. Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments. Invest Ophthalmol Vis Sci 2009; 50: 3432-3437
    CrossrefPubMedGoogle Scholar