Clin Colon Rectal Surg 2013; 26(03): 186-190
DOI: 10.1055/s-0033-1351137
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Facilitating Return of Bowel Function after Colorectal Surgery: Alvimopan and Gum Chewing

Deborah Keller
1   Division of Colorectal Surgery, Department of Surgery, University Hospitals Case Medical Center, Cleveland, Ohio
,
Sharon L. Stein
1   Division of Colorectal Surgery, Department of Surgery, University Hospitals Case Medical Center, Cleveland, Ohio
› Author Affiliations
Further Information

Publication History

Publication Date:
19 August 2013 (online)

Abstract

Postoperative ileus is common after colorectal surgery, and has a huge impact on hospital LOS. With the impeding cost crisis in the United States, safely reducing length of stay is essential. Chewing gum and pharmacological treatment with alvimopan are safe, simple tools to reduce postoperative ileus and its associated costs. Future research will determine if integrating these tools with laparoscopic procedures and enhanced recovery pathways is a best practice in colorectal surgery.

 
  • References

  • 1 Asgeirsson T, El-Badawi KI, Mahmood A, Barletta J, Luchtefeld M, Senagore AJ. Postoperative ileus: it costs more than you expect. J Am Coll Surg 2010; 210 (2) 228-231
  • 2 Iyer S, Saunders WB, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm 2009; 15 (6) 485-494
  • 3 Clinical Consensus Update in General Surgery. 2006. Available at: http://www.clinicalwebcasts.com/pdfs/GenSurg_WEB.pdf . Accessed
  • 4 Luckey A, Livingston E, Taché Y. Mechanisms and treatment of postoperative ileus. Arch Surg 2003; 138 (2) 206-214
  • 5 Baig MK, Wexner SD. Postoperative ileus: a review. Dis Colon Rectum 2004; 47 (4) 516-526
  • 6 Story SK, Chamberlain RS. A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus. Dig Surg 2009; 26 (4) 265-275
  • 7 Livingston EH, Passaro Jr EP. Postoperative ileus. Dig Dis Sci 1990; 35 (1) 121-132
  • 8 Waldhausen JH, Shaffrey ME, Skenderis II BS, Jones RS, Schirmer BD. Gastrointestinal myoelectric and clinical patterns of recovery after laparotomy. Ann Surg 1990; 211 (6) 777-784 , discussion 785
  • 9 Kentwenter J. The vagal control of duodenal and ileal motility and blood flow. Acta Physiol Scand 1965; 63: 1-68
  • 10 Bederman SS, Betsy M, Winiarsky R, Seldes RM, Sharrock NE, Sculco TP. Postoperative ileus in the lower extremity arthroplasty patient. J Arthroplasty 2001; 16 (8) 1066-1070
  • 11 Deloof S, Croix D, Tramu G. The role of vasoactive intestinal polypeptide in the inhibition of antral and pyloric electrical activity in rabbits. J Auton Nerv Syst 1988; 22 (2) 167-173
  • 12 Zittel TT, Lloyd KCK, Rothenhöfer I, Wong H, Walsh JH, Raybould HE. Calcitonin gene-related peptide and spinal afferents partly mediate postoperative colonic ileus in the rat. Surgery 1998; 123 (5) 518-527
  • 13 Espat NJ, Cheng G, Kelley MC, Vogel SB, Sninsky CA, Hocking MP. Vasoactive intestinal peptide and substance P receptor antagonists improve postoperative ileus. J Surg Res 1995;
  • 14 De Winter BY, Robberecht P, Boeckxstaens GE , et al. Role of VIP1/PACAP receptors in postoperative ileus in rats. Br J Pharmacol 1998; 124 (6) 1181-1186
  • 15 Taché Y, Mönnikes H, Bonaz B, Rivier J. Role of CRF in stress-related alterations of gastric and colonic motor function. Ann N Y Acad Sci 1993; 697: 233-243
  • 16 Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology 2000; 118 (2) 316-327
  • 17 Ogilvy AJ, Smith G. The gastrointestinal tract after anaesthesia. Eur J Anaesthesiol Suppl 1995; 10: 35-42
  • 18 Prasad M, Matthews JB. Deflating postoperative ileus. Gastroenterology 1999; 117 (2) 489-492
  • 19 Marret E, Remy C, Bonnet F. Postoperative Pain Forum Group. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg 2007; 94 (6) 665-673
  • 20 Kronberg U, Kiran RP, Soliman MS , et al. A characterization of factors determining postoperative ileus after laparoscopic colectomy enables the generation of a novel predictive score. Ann Surg 2011; 253 (1) 78-81
  • 21 Abrahamsson H, Lyrenäs E, Dotevall G. Effects of beta-adrenoceptor blocking drugs on human sigmoid colonic motility. Dig Dis Sci 1983; 28 (7) 590-594
  • 22 Holte K, Kehlet H. Postoperative ileus: progress towards effective management. Drugs 2002; 62 (18) 2603-2615
  • 23 Food and Drug Administration. Withdrawal of troglitazone and cisapride. JAMA 2000; 283 (17) 2228
  • 24 Cheape JD, Wexner SD, James K, Jagelman DG. Does metoclopramide reduce the length of ileus after colorectal surgery? A prospective randomized trial. Dis Colon Rectum 1991; 34 (6) 437-441
  • 25 Liu SS, Hodgson PS, Carpenter RL, Fricke Jr JRJ. ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia. Clin Pharmacol Ther 2001; 69 (1) 66-71
  • 26 Herzog TJ, Coleman RL, Guerrieri Jr JPJ , et al. A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy. Am J Obstet Gynecol 2006; 195 (2) 445-453
  • 27 Taguchi A, Sharma N, Saleem RM , et al. Selective postoperative inhibition of gastrointestinal opioid receptors. N Engl J Med 2001; 345 (13) 935-940
  • 28 Delaney CP, Weese JL, Hyman NH , et al; Alvimopan Postoperative Ileus Study Group. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum 2005; 48 (6) 1114-1125 , discussion 1125–1126, author reply 1127–1129
  • 29 Delaney CP, Wolff BG, Viscusi ER , et al. Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies. Ann Surg 2007; 245 (3) 355-363
  • 30 Tan EK, Cornish J, Darzi AW, Tekkis PP. Meta-analysis: alvimopan vs. placebo in the treatment of post-operative ileus. Aliment Pharmacol Ther 2007; 25 (1) 47-57
  • 31 Ludwig K, Viscusi ER, Wolff BG, Delaney CP, Senagore A, Techner L. Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis. World J Surg 2010; 34 (9) 2185-2190
  • 32 Büchler MW, Seiler CM, Monson JR , et al. Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study. Aliment Pharmacol Ther 2008; 28 (3) 312-325
  • 33 Augestad KM, Delaney CP. Postoperative ileus: impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. World J Gastroenterol 2010; 16 (17) 2067-2074
  • 34 Barletta JF, Asgeirsson T, El-Badawi KI, Senagore AJ. Introduction of alvimopan into an enhanced recovery protocol for colectomy offers benefit in open but not laparoscopic colectomy. J Laparoendosc Adv Surg Tech A 2011; 21 (10) 887-891
  • 35 Itawi EA, Savoie LM, Hanna AJ, Apostolides GY. Alvimopan addition to a standard perioperative recovery pathway. JSLS 2011; 15 (4) 492-498
  • 36 Bell TJ, Poston SA, Kraft MD, Senagore AJ, Delaney CP, Techner L. Economic analysis of alvimopan in North American Phase III efficacy trials. Am J Health Syst Pharm 2009; 66 (15) 1362-1368
  • 37 Absher RK, Gerkin TM, Banares LW. Alvimopan use in laparoscopic and open bowel resections: clinical results in a large community hospital system. Ann Pharmacother 2010; 44 (11) 1701-1708
  • 38 Gaines SL, Giroux K, Thomas S, Gregory JS. Real world efficacy of alvimopan on elective bowel resection patients: an analysis of statistical versus clinical significance. Am J Surg 2012; 203 (3) 308-311 , discussion 311–312
  • 39 Asao T, Kuwano H, Nakamura J, Morinaga N, Hirayama I, Ide M. Gum chewing enhances early recovery from postoperative ileus after laparoscopic colectomy. J Am Coll Surg 2002; 195 (1) 30-32
  • 40 Soffer EE, Adrian TE. Effect of meal composition and sham feeding on duodenojejunal motility in humans. Dig Dis Sci 1992; 37 (7) 1009-1014
  • 41 Stern RM, Crawford HE, Stewart WR, Vasey MW, Koch KL. Sham feeding. Cephalic-vagal influences on gastric myoelectric activity. Dig Dis Sci 1989; 34 (4) 521-527
  • 42 Shang H, Yang Y, Tong X, Zhang L, Fang A, Hong L. Gum chewing slightly enhances early recovery from postoperative ileus after cesarean section: results of a prospective, randomized, controlled trial. Am J Perinatol 2010; 27 (5) 387-391
  • 43 Stewart BT, Woods RJ, Collopy BT, Fink RJ, Mackay JR, Keck JO. Early feeding after elective open colorectal resections: a prospective randomized trial. Aust N Z J Surg 1998; 68 (2) 125-128
  • 44 Berghmans TM, Hulsewé KW, Buurman WA, Luyer MD. Stimulation of the autonomic nervous system in colorectal surgery: a study protocol for a randomized controlled trial. Trials 2012; 13: 93
  • 45 Schuster R, Grewal N, Greaney GC, Waxman K. Gum chewing reduces ileus after elective open sigmoid colectomy. Arch Surg 2006; 141 (2) 174-176
  • 46 Matros E, Rocha F, Zinner M , et al. Does gum chewing ameliorate postoperative ileus? Results of a prospective, randomized, placebo-controlled trial. J Am Coll Surg 2006; 202 (5) 773-778
  • 47 Quah HM, Samad A, Neathey AJ, Hay DJ, Maw A. Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial. Colorectal Dis 2006; 8 (1) 64-70
  • 48 Bahena-Aponte JA, Cárdenas-Lailson E, Chávez-Tapia N, Flores-Gama F. [Usefulness of chewing gum for the resolution of postoperative ileus in left colon resections]. Rev Gastroenterol Mex 2010; 75 (4) 369-373
  • 49 Zaghiyan K, Felder S, Ovsepyan G , et al. A prospective randomized controlled trial of sugared chewing gum on gastrointestinal recovery after major colorectal surgery in patients managed with early enteral feeding. Dis Colon Rectum 2013; 56 (3) 328-335
  • 50 Chan MK, Law WL. Use of chewing gum in reducing postoperative ileus after elective colorectal resection: a systematic review. Dis Colon Rectum 2007; 50 (12) 2149-2157
  • 51 Hocevar BJ, Robinson B, Gray M. Does chewing gum shorten the duration of postoperative ileus in patients undergoing abdominal surgery and creation of a stoma?. J Wound Ostomy Continence Nurs 2010; 37 (2) 140-146
  • 52 de Castro SM, van den Esschert JW, van Heek NT , et al. A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus. Dig Surg 2008; 25 (1) 39-45
  • 53 Purkayastha S, Tilney HS, Darzi AW, Tekkis PP. Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg 2008; 143 (8) 788-793
  • 54 Noble EJ, Harris R, Hosie KB, Thomas S, Lewis SJ. Gum chewing reduces postoperative ileus? A systematic review and meta-analysis. Int J Surg 2009; 7 (2) 100-105
  • 55 Vásquez W, Hernández AV, Garcia-Sabrido JL. Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials. J Gastrointest Surg 2009; 13 (4) 649-656
  • 56 Fitzgerald JE, Ahmed I. Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. World J Surg 2009; 33 (12) 2557-2566
  • 57 Parnaby CN, MacDonald AJ, Jenkins JT. Sham feed or sham? A meta-analysis of randomized clinical trials assessing the effect of gum chewing on gut function after elective colorectal surgery. Int J Colorectal Dis 2009; 24 (5) 585-592
  • 58 Yeh YC, Klinger EV, Reddy P. Pharmacologic options to prevent postoperative ileus. Ann Pharmacother 2009; 43 (9) 1474-1485
  • 59 McCormick JT, Garvin R, Cuashaj P , et al. The effects of gum-chewing in bowel function and hospital stay after laparoscopic vs open colectomy: a multi-institutional prospective randomized trial. J Am Coll Surg 2005; 201: s66-s67
  • 60 McCormick JT. Gum in the postoperative setting: something to chew on. Dis Colon Rectum 2013; 56 (3) 273-274
  • 61 Poulton TJ. Gum chewing during pre-anesthetic fasting. Paediatr Anaesth 2012; 22 (3) 288-296