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Semin Liver Dis 2013; 33(01): 062-070
DOI: 10.1055/s-0033-1338115
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hepatitis E Virus Infection in Immunosuppressed Patients: Natural History and Therapy

Nassim Kamar
1   Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
2   INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France
3   Université Paul Sabatier, Toulouse, France
,
Lionel Rostaing
1   Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
2   INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France
3   Université Paul Sabatier, Toulouse, France
,
Jacques Izopet
2   INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France
3   Université Paul Sabatier, Toulouse, France
4   Department of Virology, CHU Purpan, Toulouse, France
› Author Affiliations
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Publication History

Publication Date:
05 April 2013 (online)

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Abstract

Interest in hepatitis E virus (HEV) infection has increased over the last few years since chronic HEV infection was first reported in transplant patients. Chronic genotype-3 HEV infections have been now reported in patients with a solid-organ transplant, hematology disease, and in those who are human immunodeficiency virus-positive. Cases of HEV-related cirrhosis have been also reported. Furthermore, HEV associated extrahepatic manifestations, including neurologic symptoms, kidney injuries, and hematological disorders, have been reported. Antiviral therapies, such as pegylated-interferon and ribavirin, have been found to be efficient in treating HEV infection. The aim of this review is to summarize the incidence, natural history, risk factors, and treatment of HEV infections in immunosuppressed patients. HEV-induced extrahepatic manifestations are described.

Keywords

hepatitis E virus - HEV - chronic infection - cirrhosis - ribavirin - extrahepatic symptoms
 

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